Description
R-spondin-2 activates the canonical Wnt signaling pathway by serving as a ligand for LGR4-6 receptors. When it binds to LGR4, LGR5, or LGR6, these receptors interact with phosphorylated LRP6 and frizzled receptors activated by extracellular Wnt receptors, thereby initiating the canonical Wnt signaling pathway and enhancing target gene expression. Rspo2 is essential for various developmental and functional processes in mice, impacting the nervous system, bones, lungs, muscles, facial structure, and taste maintenance. Particularly in osteoblasts, Rspo2 is crucial for promoting activity and bone mineral formation via the Wnt/β-catenin signaling pathway. Research indicates that Rspo2 deficiency results in diminished bone mineralization and formation, reduced bone density, fewer trabeculae, and a lower bone volume fraction