Description
Rabbits are widely used as models for studying reproductive biology and pregnancy. Their characteristics such as precise gestation stages, high cell counts and blastocyst formation rates make them ideal for studying the regulation of pregnancy. In rabbits, the PGR gene encodes the progesterone receptor. This receptor, along with steroid hormones, plays a crucial role in regulating eukaryotic gene expression and influences cell proliferation and differentiation within target tissues. It acts as a transcriptional activator for several progesterone-dependent promoters across various cell types and is involved in the activation of SRC-dependent MAPK signaling upon hormone stimulation