Description
Superoxide dismutase [Cu-Zn] neutralizes radicals typically generated within cells that are toxic to biological systems. It is encoded by the SOD1 gene. This protein is a cytosolic, dimeric, carbohydrate-free molecule found ubiquitously, and is part of a family of isoenzymes involved in scavenging superoxide anions. In a rabbit cardiac ischemia-reperfusion model, SOD use significantly improves myocardial function and structure and reduces cardiomyocyte apoptosis and necrosis. Exogenous SOD protects against superoxide anion damage and delays atherosclerosis progression in a rabbit model of atherosclerosis