Description
Interleukin-28B, also known as interferon lambda-3 or IL28B, is a secretory cytokine belonging to the IL-28/IL-29 family. IL-28 has been shown to play a role in adaptive immune response. IL28B possesses immunoregulatory activity and upregulates the expression of MHC class I antigens, demonstrating strong antiviral and antitumor activities. Research has shown that chicken IFN-lambda markedly inhibited replication of various virus strains, including highly pathogenic influenza A viruses, in ovo and in vivo, as well as in epithelium-rich tissue and cell culture systems