Description
The Slit homolog 2 protein is believed to function as a molecular guidance cue in cellular migration, primarily through its interaction with the roundabout homolog receptors. It plays a critical role in neural development by directing axonal navigation at the ventral midline of the neural tube and aiding the projection of axons to various regions. Both SLIT1 and SLIT2 are crucial for ensuring proper midline guidance in the forebrain by serving as a repulsive signal that prevents axons from the olfactory bulb from incorrectly crossing the midline. In the mouse spinal cord, Slit2 directs axons to follow the correct path via Robo receptors, preventing them from reversing course or straying into incorrect areas. Additionally, Slit2 has been observed to hinder the migration of retinal ganglion cell axons