Description
One of the putative pathomechanisms of complement-mediated delayed neuronal cell death has been attributed to the formation of the membrane attack complex (MAC/C5b-9) following terminal complement activation. The formation of C5b-9 and sC5b-9 occurs due to activation of the complement system through the classical, lectin, or alternative pathways. The soluble terminal complement complex sC5b-9 represents a potential novel serum biomarker specific for isolated head injury