Fig 1: Colocalization analysis of MUC20 in OP and MASLD. (A) Scatter plot comparing MUC20 eQTL significance and OP GWAS significance across shared SNPs. (B) Scatter plot comparing MUC20 eQTL significance and MASLD GWAS significance across shared SNPs. The x-axis indicates MUC20 eQTL −log10(p), and the y-axis indicates disease GWAS −log10(p).
Fig 2: Comparison of serum MUC20 levels between the two groups. **** p < 0.0001.
Fig 3: Network-based and knowledge-based characterization of MUC20. (A) GeneMANIA interaction network of MUC20 and its functional neighborhood, highlighting glycosylation-related modules. (B) Gene–disease associations for MUC20 curated from the CTD. (C) Predicted miRNA regulators of MUC20 from miRDB. (D) Gene–chemical associations for MUC20 from CTD. These analyses provide functional and translational context for subsequent hypothesis testing.
Fig 4: Macrophage-focused in silico perturbation of MUC20 in osteoporosis and predicted downstream transcriptional programs. (A) MUC20 expression in macrophages from control and OP samples. (B) Proportion of significantly altered genes following simulated MUC20 perturbation. (C) Distribution of predicted downstream transcriptional changes after MUC20 perturbation, with representative genes labeled. (D) Top predicted downstream genes ranked by perturbation effect size and grouped by functional modules. (E) GO enrichment of perturbation-associated genes. (F) KEGG enrichment of perturbation-associated genes. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Supplier Page from Fine Biotech Co., Ltd. for Human MUC20 (Mucin-20) QuickTest ELISA Kit