Fig 1: Angio‐3 inhibited coagulation activation and PAR‐1 expression in BLM‐induced mice. (A–D) The coagulation system marker TF (n = 8), TAT (n = 8), FX (n = 7), FXII (n = 7). In plasma of mice were detected by ELISA. (E) Representative immunohistochemical staining of FX in lung sections (scale bars, 100 μm). (F) Quantitative analysis of FX expression shown in (E) (n = 8). (G) Immunofluorescence costaining of PAR‐1 (red), FSP‐1 (green) and DAPI (blue) in lung tissues (scale bars, 20 μm). (H) Quantitative analysis of PAR‐1 in lung sections of mice (n = 5). Data are presented as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.