Fig 2: Comparisons of JAM2 (A), Collagen I (B) and MMP2 (C) levels in vaginal wall tissues between patients with pelvic organ prolapse (POP, n = 82) and controls (n = 64). Violin plot, ***p < 0.001 from Unpaired t‐test with Welch's correction. Pearson correlation analysis of JAM2 and Collagen I levels (D), JAM2 and MMP2 levels (E), Collagen I and MMP2 levels (F) in vaginal wall tissues from patients with pelvic organ prolapse (POP, n = 82).

Fig 3: Comparisons of mRNA expressions of JAM2 (A), Collagen I (B) and MMP2 (C) levels in vaginal wall tissues between patients with pelvic organ prolapse (POP, n = 82) and controls (n = 64). Violin plot, ***p < 0.001 from Unpaired t‐test with Welch's correction. Pearson correlation analysis of JAM2 and Collagen I mRNA expressions (D), JAM2 and MMP2 mRNA expressions (E), Collagen I and MMP2 mRNA expressions (F) in vaginal wall tissues from patients with pelvic organ prolapse (POP, n = 82).

Fig 4: ROC analysis of JAM2, Collagen I and MMP2 levels in vaginal wall tissues (A) and mRNA expressions of JAM2, Collagen I and MMP2 levels in vaginal wall tissues (B) for the distinguishing of pelvic organ prolapse from controls.

Fig 5: Spearman correlation analysis of POP‐Q grade with mRNA expressions of JAM2 (A), Collagen I (B) and MMP2 (C) levels in vaginal wall tissues from patients with pelvic organ prolapse (POP, n = 82).