Description
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.
The major full-length protein contains 627 amino acids forming 3 known functional domains: an N-terminal FERM domain that localizes the protein to the plasma membrane, a central helical alpha-domain, and a C-terminal actin-binding domain. By immunohistochemical analysis of mouse inner ear