Description
Both MIP-1a and MIP-1b are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens, by regulating the trafficking, and activation state, of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1a and MIP-1b exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1a selectively attracting CD8+ lymphocytes, and MIP-1b selectively attracting CD4+ lymphocytes. Additionally, MIP-1a and MIP-1b have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells.
Rat MIP-1beta (CCL4) Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure MIP-1beta (CCL4) with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for MIP-1beta (CCL4). It contains E Coli-expressed recombinant MIP-1beta (CCL4). The detection antibody is a biotinylated goat polyclonal antibody specific for MIP-1beta (CCL4). The kit is analytically validated with ready to use reagents