Description
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Ralpha and gp130. While the IL-6Ralpha chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Ralpha. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Ralpha alone. IL-6Ralpha is expressed in a wide range of cells, including T cells, fibroblasts and macrophages.
Human IL-6 Receptor Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure IL-6 Receptor with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for IL-6 Receptor. It contains sf21-expressed recombinant IL-6 Receptor. The detection antibody is a biotinylated goat polyclonal antibody specific for IL-6 Receptor. The kit is analytically validated with ready to use reagents