Description
Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform.
Human FLT-3 Ligand Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure FLT-3 Ligand with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for FLT-3 Ligand. It contains sf21-expressed recombinant FLT-3 Ligand. The detection antibody is a biotinylated goat polyclonal antibody specific for FLT-3 Ligand. The kit is analytically validated with ready to use reagents