Fig 1: Inhibition of high glucose-induced oxidative stress and inflammation through suppression of PKC/HMGB1/RAGE/NF?B pathway by verbascoside. (A) SOD and (B) 8-OHdG assays were used to assess oxidative stress of high glucose-cultured cells following inhibition of PKC/HMGB1/RAGE/NF?B signaling; the high glucose-elicited production of IL-6 (C) and IL-1ß (D) were downregulated in cells treated with verbascoside, NAC, or PKC inhibitor. * indicates p < 0.05 compared to the control group (CON); # indicates p < 0.05 compared to the high glucose group (HG).
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