Fig 1: Enzyme-linked immunosorbent assays (ELISA) validation and quantification of serum levels of proteins differentially expressed between NR (red) and SR (green). Statistical analysis corroborated the presence of significant higher levels in SR of SERPINE1 (A) and ARHGAP35 (B) and significant higher levels of DEFA1 (D) and CD300a (E) in NR. Mann-Whitney test was conducted in A, B, C, D, F, H and I. Student’s t-test was applied in E and G. * p < 0.05 vs. SR; ** p < 0.01 vs. SR.ADDITIONAL MATERIAL:Additional File 1: File name: SUPFIG1 MOD.tif File format: .tif