Description
Qualitative Enzyme immunoassay for detection of E7 oncoproteins from Human Papillomavirus (HPV) types 16, 18, and 45 in cervical smears.
Human Papillomaviruses (HPV) are sexually transmitted viruses frequently occurring all over the world. Almost everyone comes into contact with at least one HP virus during the course of his/her life. In most cases, the infection heals on its own. In rare cases, chronic persistent infections can cause health problems. So far, more than 200 virus types are known of which approximately 40 affect the genitals. Some of these viruses are responsible for the formation of benign genital warts while other types, the so-called high risk types, contribute significantly to the development of cervical, anal, and penile carcinoma and cancer in the area of mouth and throat. The high risk HPV types 16 and 18 are found in 70% of cervical cancer. However, type 45 is also highly associated with risk, particularly for adenocarcinoma, a very aggressive type of cervical cancer.
HPV E7 oncoprotein shares functional similarities (tumor initiation and induction of genomic instability) with such proteins as adenovirus E1A and SV40 large tumor antigen.
HPV E7 plays a central role in both the viral life cycle and carcinogenic transformation.
HPV E7 disrupts the association between cellular differentiation and proliferation in normal epithelium, allowing for viral replication in cells that would no longer be in the dividing population.
recomWell HPV 16/18/45: Secure and simple ELISA format
clear and qualitative results based on the measurement of absorbances.
break-aparts: processing of up to 96 individual samples per run possible