Dicer-Substrate Short Interfering RNAs (DsiRNAs) and TriFECTa™ Kits from Integrated DNA Technologies

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ItemDicer-Substrate Short Interfering RNAs (DsiRNAs) and TriFECTa™ Kits
CompanyIntegrated DNA Technologies
Price Supplier Page View Company Product Page
Catalog NumberDsiRNAs
ApplicationsRNAi

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Integrated DNA Technologies

1710 Commercial Park

Coralville, Iowa 52241

United States

Phone: 800-328-2661

Company Profile

Website: http://www.idtdna.com

(1) SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cellsPLoS PathogMarch 19, 2026Pak-Hin Hinson Cheung, Pearl Chan, Hua Yang, Krisztina Ambrus, Shravya Honne, Baek Kim, Stanley Perlman, Li Wurespectively named KO2/vec or KO2/KI were used for subsequent studies. RNA interference and transfection DsiRNAs were oligo-duplex and the sequences were predesigned by Integrated DNA Technologies (IDT) [99]. Cells

(2) LncRNA Dlx4os drives malignant transformation and phenotype switching in melanomaEpigeneticsMarch 19, 2026Ana Luisa Pedroso Ayub, Beatriz Cristina Biz Tonin, Hátylas Azevedo, Pedro Henrique Fogaça Jordão, Tanvi Saxena, Leinal Sejour, Jeremie Nsengimana, Ioannis Vlachos, Eduardo Moraes Reis, Frank John Slack, et al.by qPCR. Knockdown of Dlx4 and Dlx4os The 4C11- melanoma cell line was transfected with 10 nM of DsiRNAs (Dicer-substrate short interfering RNAs) DsiDlx4os (1, 2 or 3), DsiDlx4, or DsiControl (scramble) from

(3) Downregulation of the Long Non-Coding RNA MDL1AS Alters Metabolism, Differentiation, and Radiosensitivity in NTERA2 and SH-SY5Y CellsCancers (Basel)March 12, 2026Adrián Casas-Benito, Pablo Garrido, Alfredo Martínezphysiology experiments, MDL1AS expression was downregulated with Dicer-substrate small interfering RNAs (DsiRNAs), as described [31]. DsiRNAs against MDL1AS were synthesized at a 10 nmol scale by Integrated DNA Technologies

(4) Pyrimidinergic calcium signaling links tubular metabolism to fibrosis in kidney diseaseNature CommunicationsFebruary 19, 2026Andreja Figurek, Nevena Jankovic, Sarah Kollar, Monika Kaminska, Imene Sakhi, Anna Rinaldi, Pietro E. Cippà, Bernard Robaye, Andrew M. Hallwas performed by transfecting wild-type NRK-49F cells with Dicer-substrate short interfering RNAs (DsiRNAs) targeting P2RY6 (TriFECTa RNAi Kit; IDT Technology) using the Lipofectamine™ RNAiMAX Transfection Reagent

(5) Hormetic Effects of 7-Ketocholesterol in Preventing Ferroptosis in HepatocytesOxid Med Cell LongevFebruary 11, 2026Sarit Anavi, Nicole Giltman, Haim Zeigerman, Zecharia Madar, Oren TiroshTriFECTa kit DsiRNA protocol by Integrated DNA Technologies, Inc. (IDT). Each of the three predesigned DsiRNAs‐ mm.Ri.Cyp51.13.1(#:239213079), mm.Ri.Cyp51.13.2 (#:239213082), mm.Ri.Cyp51.13.3 (#:239213985) was used

(6) Mitotic chromatin compaction tethers extrachromosomal DNA to chromosomes and prevents their mis-segregation into micronucleiJournal of Biological ChemistryFebruary 1, 2026Lu M. Yangused, including non-targeting siRNA (siControl), hs.Ri.MKI67.13.1 (siMKI67 #1), and hs.Ri.MKI67.13.2 dsiRNAs (siMKI67 #2), both targeting exon 13 of MKI67 (NM_002417). Cells were forward transfected using Lipofectamine RNAiMAX Transfection Reagent

(7) TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilienceNature CommunicationsJanuary 30, 2026Yiechang Lin, Zijing Zhou, Yaoyao Han, Delfine Cheng, Haoqing Jerry Wang, Lining Arnold Ju, Yixiao Zhang, Charles D. Cox, Ben Corryintensity. Mechano-resilience assay Human Oligodendroglioma were transfected with control dsiRNA or dsiRNAs targeting TMEM63A (gaccaaagucuacauauu) or TMEM63B (gucaugaccuacaguauc) (IDT) with Lipofectamine RNAiMax

(8) Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancerCell Death DiscoveryJanuary 19, 2026Silvia Sabbioni, Paola Guerriero, Ram C. Shankaraiah, Laura Masatti, Angelo Michilli, Cristian Bassi, Lucilla D’Abundo, Farzaneh Moshiri, Bruno De Siena, Edi Simoni, et al.and was administered daily by intraperitoneal injection (i.p). Transfection Dicer-substrate siRNAs (DsiRNAs) are chemically synthesized 27mer RNA duplexes processed by Dicer, characterized by an increased potency

(9) Planar cell polarity protein Vangl2 interacts with M-cadherin and stabilizes its cell surface expression in mouse C2C12 myoblastsFrontiers in Cell and Developmental BiologyJanuary 16, 2026Tadahiro Nagaoka, Erina Sasaki, Sakiho Takagi, Masashi Kishi, Keisuke Hitachi, Kunihiro TsuchidaFisher Scientific). The PCR primers used to construct the plasmids are listed in Supplementary Table S2. DsiRNAs were purchased from Integrated DNA Technologies (Coralville, IA, United States), and their sequences

(10) Pharmacological activation of p53 induces dose-dependent changes in endothelial cell fate during angiogenic sproutingCell Death DisDecember 8, 2025Omayma Al-Radi, Katrine Ingelshed, Lisa Eichhorn, Heidi Josefsson, Martin Krkoska, Lars Bräutigam, Susanne Lindström, Ákos Végvári, Sania Kheder, Carmine P. Cerrato, et al.transfection efficiency were purchased as part of the TriFECTa RNAi Kit (hs.Ri.TP53.13, Integrated DNA Technologies). The DsiRNAs were reconstituted in nuclease-free water, diluted in duplex buffer, and stored in aliquots at −20 °C

(11) Lysine demethylase 5D promotes CHEK1 inhibitor sensitivity through p38-mediated cyclooxygenase-2 expression in castration-resistant prostate cancer cellsThe Journal of Pharmacology and Experimental TherapeuticsDecember 1, 2025Wenxiao Zheng, Shichen Li, Raymond E. West, Ella R. Donahue, Thomas D. Nolin, Song Li, Qiming Jane Wangand Western blotting. 2.4 Small interfering RNA transfection Dicer-substrate small interfering RNAs (DsiRNAs) targeting KDM5D or p38 and nontargeting DsiRNA were obtained from Integrated DNA Technologies. Cells

(12) Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organizationiScienceDecember 1, 2025Masaki Hosogane, Sue-yi Siao, Atsushi Hatano, Xiaoxin Huang, Yuichi Shichino, Yasuaki Watanabe, Shintaro Iwasaki, Masaki Matsumoto, Keiko Nakayamaperformed as described above. RNAi experiments Negative control Dicer-Substrate Short Interfering RNAs (DsiRNAs) and DsiRNAs targeting CDR2 (hs.Ri.CDR2.13.2 and hs.Ri.CDR2.13.3) and CDR2L (hs.Ri.CDR2L.13.2) were

(13) Transglutaminase 7 Silencing Inhibits Proliferation and Modulates Inflammatory and Apoptotic Markers in Testicular Germ Cell TumorsOncology ResearchNovember 27, 2025Rawabi S. Altuwayjiri, Ibtesam S. AlmamiTechnique Short interfering RNAs (siRNAs) targeting TGM7 were designed using Dicer-Substrate siRNAs (DsiRNAs) from the TriFECTa® Kit (CAT#RNA-10025-PR, Integrated DNA Technology, Coralville, IA, USA). Transfection

(14) A shared gene but distinct dynamics regulate mimicry polymorphisms in closely related butterfly speciesProceedings of the Royal Society B: Biological SciencesNovember 26, 2025Sofia I. Sheikh, Meredith M. Doellman, Nicholas W. VanKuren, Phoebe Hall, Marcus R. Kronforstof pupation when the cuticle was still labile. For injections, we designed Dicer substrate siRNAs (DsiRNAs) using IDT’s DsiRNA design tool and a P. lowii genome (see below), identifying off-target sites with

(15) ZC3H4, a novel regulator of mitochondrial complex I, impacts prostate stromal cell senescence, attachment, adhesion and anoikis resistanceCell Death DisOctober 21, 2025Teresa T. Liu, Mia J. Carrarini, Livianna K. Myklebust, Kegan O. Skalitzky, Nathalie El-Khoury, Ian J. Sipula, Alexander Chang, Vishal Soman, Ailing Liu, Nnamdi Ihejirika, et al.(Cat# T-2001-03, Horizon, Lafayette, CO, USA) in serum-free and antibiotics-free media. The following dsiRNAs from IDT were utilized for knockdown experiments either individually, or as a pool: siZC3H4 #1, 5’GACUACGAGAAUGAGCAGUAUGGGG-3’

(16) DsiRNA‐mediated silencing of Ceratitis capitata transformer or transformer‐2 leads to masculinization of XX embryos and systemic gene silencing in ovariesInsect ScienceOctober 5, 2025Gennaro Volpe, Sarah Maria Mazzucchiello, Domenico De Falco, David Torrente, Stefania Liguori, Noemi Rosati, Dora Baccaro, Michela Mazzeo, Fulvio Bertolotto, Harshini Sangle, et al.targets for RNAi‐mediated masculinization of XX individuals (Pane et al., 2002; Salvemini et al., 2009). DsiRNAs were designed using the Integrated DNA Technologies (IDT, Coralville, IA) online tool and verified for

(17) LncRNA CASC19 promotes pancreatic cancer progression by increasing PSPC1 protein stability and facilitating the oncogenic PSPC1/ β-Catenin pathwayMolecular MedicineSeptember 29, 2025Moumita Mukherjee, Swati Ghosh, Atanu Maity, Sukanta Ray, Hemabha Saha, Ranjit Prasad Bahadur, Srikanta Goswamitransfected MIAPaCa-2 cells were selected using 1.5 µg/mL of geneticin for 14 days. For knockdown, CASC19 DsiRNAs and a scramble DsiRNA (IDT, catalog no.: 51-01-14-03) were purchased from IDT (Integrated DNA Technologies,

(18) HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latencyNature MicrobiologySeptember 26, 2025Leah M. Plasek Hegde, Lalith S. Gunawardane, Farshad Niazi, Uri Mbonye, Konstantin Leskov, Gani Perez, Curtis Dobrowolski, Meenakshi Shukla, William S. Nutt, Jonathan Karn, et al.per ml and supplemented with 60 IU ml−1 IL-2 or quiescence-inducing cytokine cocktail. Information on dsiRNAs used in this study (sourced from IDT) is as follows: Immunofluorescence cytochemistry assays For immunofluorescence

(19) Spatiotemporal coordination of reovirus peripheral core replication to perinuclear whole virus assemblyPLoS pathogensSeptember 1, 2025Kniert J, Terino D, Eaton HE, Lin QF, Wu SY, Strickfaden H, Shmulevitz M.particles. DsiRNA-mediated knockdowns For DsiRNA knock-down studies, cells were transfected with DsiRNAs (Integrated DNA Technology) directed against either a non-targeting control (G7L, vaccinia virus gene,

(20) Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotesCellJuly 24, 2025Michael B. Gilbert, Karl M. Glastad, Maxxum Fioriti, Matan Sorek, Tierney Scarpa, Freddy S. Purnell, Daniel Xu, Lindsay K. Pino, Anatoly Korotkov, Ali Biashad, et al.volume and brain number. RNAi Injections for Neuroparsin-A and VKR Custom short interfering RNAs (dsiRNAs) targeting Neuroparsin-A and VKR were synthesized by IDT. DsiRNAs were resuspended to 20μM. 10 μL aliquots

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Dicer-Substrate Short Interfering RNAs (DsiRNAs) and TriFECTa™ Kits from Integrated DNA Technologies

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Dicer-Substrate Short Interfering RNAs (DsiRNAs) and TriFECTa™ Kits from Integrated DNA Technologies

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