Description
Product Characteristics: For the quantitative determination of mouse disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) concentrations in serum, plasma, tissue homogenates.
Target Information: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\, binds mitotic arrest deficient 2 protein\, and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]