Fig 1: Animal grouping and the experimental design of the present study. Abbreviations: Bcl-2, beta cell lymphoma-2; BLM, bleomycin; HO-1, heme oxygenase-1; IL-1β, interleukin-1 beta; LC3-II, microtubule-associated protein 1 light chain 3; NLRP3, NOD-like receptor family pyrin domain-containing; Nrf2, nuclear factor erythroid 2–related factor 2; P62, sequestosome 1; SIRT1, sirtuin-1; TGF-β1, transforming growth factor beta 1, TXNIP, thioredoxin-interacting protein.
Fig 2: Alogliptin with or without amentoflavone combated the changes in the lung tissue TXNIP/NLRP3 inflammasome/gasdermin D axis induced by bleomycin. Results are presented as mean ± standard deviation (SD) (number of animals = 10 per group) and statistically analyzed using one-way ANOVA, followed by Tukey’s multiple comparison test. A p-value < 0.05 was considered significant. Abbreviations: AMV, amentoflavone; ALG, alogliptin; BLM, bleomycin; NLRP3, NOD-like receptor protein 3; TXNIP, thioredoxin-interacting protein.
Supplier Page from Biorbyt for Mouse NLRP3 ELISA Kit (Ready to Use)
Application Notes: serum, plasma, tissue homogenates and other biological fluids.