Fig 1: NIA performance table and conceptual home-based sample collection and centralized NIA analysis. (A) Comparison between the high-throughput NIA platform and standard ELISA. Sensitivity and specificity values are based on serum sample analysis for both NIA and ELISA. Entries with superscript a are based on EuroImmun ELISA kit (EI 2606-9601) (29), those with superscript b are based on ref. 23, and those with superscript c are priced based on Abcam ELISA kit (ab274342). (B) An NIA-based diagnostic workflow that uses decentralized ultralow-volume whole blood sample collection, shipping via regular mail, and centralized sample processing and analysis on a high-throughput NIA platform. Test results are analyzed and interpreted and then reported back via mobile app, email, or regular mail.