NEBNext FFPE DNA Repair Mix M6630L from New England Biolabs

Product Specs
ItemNEBNext FFPE DNA Repair Mix
CompanyNew England Biolabs
Price $622.00 Inquire
Catalog NumberM6630L
Quantity96 reactions
ApplicationsDNA Analysis, NGS
Temperature-20 C

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New England Biolabs

240 County Road

Ipswich, Massachusetts 1938

United States

Phone: 800-632-5227
800-632-7799
978-921-1350

Company Profile

Website: http://www.neb.com

(1) Mutational landscape of normal breast tissues adjacent to invasive breast cancerCell Reports MedicineJanuary 20, 2026Aleksandra Suwalska, Mariya Rozenblit, Malini Harigopal, Jiawei Dai, Meng Liu, Jeffrey P. Townsend, Michal Marczyk, Lajos Pusztaifor 5 min at 37°C followed by the addition of NEBNext FFPE DNA Repair Mix (New England BioLab, cat# M6630L) and incubation for 15 min at 20°C. DNA was sheared to a mean fragment length of 220 bp using the Covaris

(2) Towards decentralization of Salmonella serotyping and risk assessment in poultry production environments with nanopore sequencingFront MicrobiolOctober 15, 2025Ruwani Karunarathna, Chao Chun Liu, Dhinesh Periyasamy, Arnold Berg, Musangu Ngeleka, Anatoliy TrokhymchukNEBNext Ultra II End repair/dA-tailing Module (NEB, Cat no. E7546) and NEBNext® FFPE DNA Repair Mix (NEB, Cat no. M6630L) were used to add dA-tails to the ends of the amplicons, followed by magnetic bead clean up and elution

(3) Genomic insights into diversity, antimicrobial resistance and virulence of Glaesserella parasuis from diseased swine in PeruFrontiers in MicrobiologySeptember 23, 2025Luis Alvarez-Vega, Karolina S. M. De La Cruz-Monroy, Arturo Garcia-Barraza, Dennis Carhuaricra, Jose L. Llaja-Bernedo, Liseth L. Huamancha-Pulido, Alejandra Medina-Gonzales, Andre F. Sedano-SanchezNanopore, UK) following the ligation protocol. Briefly, DNA was repaired using FFPE DNA Repair Mix (M6630L, New England Biolabs, USA) and A-tails were added using the Ultra II End Repair/dA-Tailing Module (E7546L,

(4) A telomere‐to‐telomere gap‐free assembly integrating multi‐omics uncovers the genetic mechanism of fruit quality and important agronomic trait associations in pomegranatePlant Biotechnology JournalMay 3, 2025Lina Chen, Hao Wang, Tingtao Xu, Ruitao Liu, Juanli Zhu, Haoxian Li, Huawei Zhang, Liying Tang, Dan Jing, Xuanwen Yang, et al.High‐molecular‐weight genomic DNA was purified by magnetic beads, after damage and end repair (NEB, M6630L and E7546L), sequencing adapters ligation (NEB, E6056S), ONT ultralong sequencing libraries were prepared

(5) Higher Microbial Abundance and Diversity in Bronchus-Associated Lymphoid Tissue (BALT) Lymphomas than in Non-Cancerous Lung TissuesCancer Research and TreatmentSeptember 30, 2024Jung Heon Kim, Jae Sik Kim, Noorie Choi, Jiwon Koh, Yoon Kyung Jeon, Ji Hyun Chang, Eung Soo Hwang, Il Han KimQiagen). Subsequently, extracted DNAs underwent a repair process utilizing a NEBNext FFPE DNA Repair Mix (M6630L, New England Biolabs). 3. DNA amplification Polymerase chain reaction (PCR) amplification of the 16S

(6) Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancerNature GeneticsJuly 3, 2024Hamzeh Kayhanian, William Cross, Suzanne E. M. van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, et al.impact of artefactual lesions due to formalin fixation31 using a validated kit (New England Biolabs, M6630L) and following the manufacturer’s protocol. Briefly, 48 μl of fragmented sample DNA was mixed with 3.5

(7) Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer CellsCancer DiscovMarch 26, 2024Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, et al.Sonication Device (Diagenode). FFPE DNA samples were treated with the NEBNext FFPE DNA-repair Mix (NEB, M6630L). DNA libraries for Illumina sequencing were prepared with the NEBNext Ultra 2 DNA Library Kit for Illumina

(8) Genomic Characterization of Carbapenem-Resistant Bacteria from Beef Cattle FeedlotsAntibiotics (Basel)May 25, 2023Sani-e-Zehra Zaidi, Rahat Zaheer, Krysty Thomas, Sujeema Abeysekara, Travis Haight, Luke Saville, Matthew Stuart-Edwards, Athanasios Zovoilis, Tim A. McAllistermix [Cat: E7646AA; New England Biolabs (NEB) Ltd. Whitby, ON, Canada] and FFPE DNA repair mix [Cat: M6630L; New England Biolabs (NEB) Ltd. Whitby, ON, Canada]. End-repaired DNA from each isolate were individually

(9) Critically short telomeres derepress retrotransposons to promote genome instability in embryonic stem cellsCell DiscoveryMay 2, 2023Nannan Zhao, Guoxing Yin, Chun Liu, Weiyu Zhang, Yang Shen, Dan Wang, Zhenzhen Lin, Jiao Yang, Jian Mao, Renpeng Guo, et al.DNA was fragmented by g-TUBE (Covaris). DNA repair was performed using NEBNext FFPE DNA Repair Mix (M6630L, NEB). End repair was performed using NEBNext Ultra II End Repair/dA-Tailing Module (E7546L, NEB). Adapter

(10) Benchmarking second and third-generation sequencing platforms for microbial metagenomicsSci DataNovember 11, 2022Victoria Meslier, Benoit Quinquis, KÃ©vin Da Silva, Florian Plaza OÃ±ate, Nicolas Pons, Hugo Roume, Mircea Podar, Mathieu Almeidaµg), of length comprised between 8 and 9 kb, underwent end repair and A-Tailing (New England Biolabs M6630L and E7546L kits). Next, 500 ng of repaired DNA was ligated with adapter barcode using Native Barcoding

(11) Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancerNature communicationsMay 10, 2022Zhou L, Qiu Q, Zhou Q, Li J, Yu M, Li K, Xu L, Ke X, Xu H, Lu B, et al.end-repaired, A-tailed, and adapter-ligated. DNA repair was conducted using NEBNext FFPE DNA Repair Mix (M6630L, NEB). DNA end repair and dA-tailing were performed using NEBNext Ultra II End Repair/dA-Tailing Module

(12) Short-read and long-read RNA sequencing of mouse hematopoietic stem cells at bulk and single-cell levelsScientific DataDecember 1, 2021Xiuran Zheng, Dan Zhang, Mengying Xu, Wanqin Zeng, Ran Zhou, Yiming Zhang, Chao Tang, Li Chen, Lu Chen, Jing-wen Linwere subjected to end-repair and dA-tailing ligation using NEBNext FFPE DNA Repair Mix (NEB, Cat No. M6630L) and NEBNext Ultra II End Repair/dA-Tailing Module (NEB, Cat No. E7645). PromethION library preparation

(13) Structural variants in the Chinese population and their impact on phenotypes, diseases and population adaptationNature CommunicationsDecember 1, 2021Zhikun Wu, Zehang Jiang, Tong Li, Chuanbo Xie, Liansheng Zhao, Jiaqi Yang, Shuai Ouyang, Yizhi Liu, Tao Li, Zhi XieDNA was Fragmented by g-TUBE (Covaris). DNA repair was performed using NEBNext FFPE DNA Repair Mix (M6630L, NEB). End repair was performed using NEBNext Ultra II End Repair/dA-Tailing Module (E7546L, NEB). Adapter

(14) Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for rapid, accurate, and affordable somatic mutation detectionGenome BiologyDecember 1, 2021Deepak Thirunavukarasu, Lauren Y. Cheng, Ping Song, Sherry X. Chen, Mitesh J. Borad, Lawrence Kwong, Phillip James, Daniel J. Turner, David Yu ZhangQiagen GeneRead DNA FFPE kit (Catalog No.180134) and repaired using NEBNext FFPE DNA repair mix (NEB #M6630L). Stochastic Amplicon Ligation (SAL). BsaI restriction sites and complementary overhangs for assembly

(15) High-resolution, ultra-sensitive and quantitative DNA double-strand break labeling in eukaryotic cells using i-BLESSNature ProtocolsFebruary 1, 2021Anna Biernacka, Magdalena Skrzypczak, Yingjie Zhu, Philippe Pasero, Maga Rowicka, Krzysztof Ginalskiwell-ventilated area, wear eye and face protection. NEBNext® FFPE DNA Repair Mix (New England Biolabs, cat.no. M6630L) Quick Blunting Kit (New England Biolabs, cat. no. E1201L) BSA (20 mg/mL, New England Biolabs, cat.

(16) 人类肠道病毒粒子富集及纳米孔测序BIO-PROTOCOLJanuary 1, 2021佳宝曹, 雨青张, 娜赵, 军王(Oxford Nanopore, catalog number: EXP-NBD104) 17. NEBNext FFPE DNA repair mix (NEB, catalog number: M6630L) 18. Ultra II End-prep enzyme mix (NEB, catalog number: E7372AA) 19. Blunt/TA ligase master mix (NEB,

(17) Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencingGenome ResearchSeptember 1, 2020Sergey Aganezov et al.standard Oxford Nanopore methods. Briefly, sheared DNA was repaired with the NEB FFPE repair module (NEB M6630L), ligated to Oxford Nanopore adapters (Oxford Nanopore SQK-LSK108) via the NEB blunt/TA master mix (NEB

(18) Isolation and analysis of rereplicated DNA by Rerep-SeqNucleic Acids ResearchJune 4, 2020Johannes Menzel, Philip Tatman, Joshua C Blacknumber M0282S for 2 h at 37°C. Digested DNA was repaired with NEB’s FFPE DNA Repair Mix, NEB catalog # M6630L, for 30 min then separated on 0.8% agarose gel for 15 min at 200V. Fragmented DNA ranging from 0.1 to

(19) Nanopore sequencing and assembly of a human genome with ultra-long readsNature BiotechnologyApril 1, 2018Miten Jain et al.

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NEBNext FFPE DNA Repair Mix

NEBNext FFPE DNA Repair Mix from New England Biolabs

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New England Biolabs

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NEBNext FFPE DNA Repair Mix from New England Biolabs

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