Fig 1: GA and 7-NI Attenuated the Major Inflammatory Mediators in MPTP-induced Mice. (a and b) Effect of GA and 7-NI on NF-κB and Cox-2 Levels Through ELISA Estimation. (c) Total NO Level in MPTP-induced Mice Brain.
Fig 2: FGF15/FGFR4 signaling inhibits M1 polarization of septic macrophages and their inflammatory responses.A Detection of the pro-inflammatory mediators TNF-α, IL-1β, IL-6, COX-2, and iNOS and anti-inflammatory mediators IL-10 and TGF-β in peripheral blood of Sham, CLP and rFGF15-treated CLP (CLP + rFGF15) mice by ELISA. n = 9, *p < 0.05. B Detection of CD86 (a marker of M1-like macrophages) and CD206 (a marker of M2-like macrophages) in mouse BMDMs and RAW264.7 macrophages following treatment with vehicle (Control), LPS, LPS + rFGF15, LPS + rFGF15 + si-NC, or LPS + rFGF15 + si-FGFR4 by flow cytometry. C Detection of the pro-inflammatory mediators TNF-α, IL-1β, IL-6, COX-2, and iNOS and anti-inflammatory mediators IL-10 and TGF-β in mouse BMDMs and RAW264.7 macrophages following treatment with vehicle (Control), LPS, LPS + rFGF15, LPS + rFGF15 + si-NC, or LPS + rFGF15 + si-FGFR4 by ELISA. n = 6, *p < 0.05.
Fig 3: The effect of BPA and/or vanadium on the levels of inflammatory and pro-inflammatory cytokines in the prefrontal cortex of the mice. (A) level of NF-κB, (B) level of MAPK-14, (C) level of nNOS, (D) level of iNOS; (E) level of COX-2, and (F) level of MPO. The data obtained was analyzed using one-way ANOVA (**P < 0.01, ****P < 0.0001). The values are presented as means ± SD (n = 5/group).
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