Fig 1: Differentially expressed serum proteins between pregnant rats with SBA fetuses and normal controls at E11 and E13.(a) The number of differentially expressed serum proteins between pregnant rats with SBA fetuses and normal controls at E11 and E13. (b) Distribution of the up-regulated and down-regulated expression of differential proteins at E11 and E13; the yellow region includes 6 proteins (sPLA2, fibroleukin, GDN, tubulin beta chain, fibrinogen-like protein 1, haptoglobin) that were up-regulated at E13 and down-regulated at E11, the green region includes 2 proteins (APOM, PCSK9) that were down-regulated at both E11 and E13, and the red region includes 2 proteins (fibrinogen gamma chain, Ig heavy chain V region MOPC 47A) that were up-regulated at both E11 and E13.
Fig 2: Expression patterns of selected protein candidates in the serum of the experimental group compared with the control group using iTRAQ analysis and ELISA validation.(a) Fold change of protein levels (the mean value of experimental group / the mean value of control group) of LIFR (E11), AMH (E11), 14-3-3E (E11), APOM (E11 and E13), and PCSK9 (E11 and E13) from iTRAQ analysis and ELISA validation. (b) Fold change of protein levels (the protein concentration of each sample/the mean concentration of control group) of LIFR (E11), AMH (E11), 14-3-3E (E11), APOM (E11 and E13), and PCSK9 (E11 and E13) from ELISA analysis (n = 6). *p < 0.05, **p < 0.01 (pregnant rats with SBA serum vs. control serum). The data are shown as the mean value ± SD. The upregulated proteins in the experimental group were above the dotted line, and the downregulated were below the dotted line.
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