Fig 1: GS‐HCl treatment ameliorates joint injury in KOA mice. KOA mouse models were established by the ACLT method. (A–C) At 3 and 7 days as well as 2, 4 and 8 weeks after modelling, blood specimens were collected from each group of mice. Serum CTX‐II, CS846 and COMP levels were measured by ELISA. n = 6; Data are presented as mean ± standard deviation, and two‐way ANOVA was used for statistical analysis, followed by Tukey's post hoc test; *p < 0.05 vs. the Sham group, # p < 0.05 vs. the low‐dose GS‐HCl group and ^ p < 0.05 vs. the high‐dose GS‐HCl group.