Fig 1: A diagnostic algorithm based on the values of hBD-2 mRNA, IVL, IVL mRNA and PSMB8 mRNA. Classification of biopsies into groups of healthy skin and inflammatory skin diseases was completed based on the results of hBD-2 mRNA (first division). Classification of biopsies into groups of AD, PV and C based on the results of hBD-2 mRNA, IVL and IVL mRNA (left lower part of the diagram) or based on the results of hBD-2 mRNA and PSMB8 mRNA (right lower part of the diagram).
Fig 2: Correlation of IVL mRNA with intensity of itch sensation in patients with atopic dermatitis (p = 0.02, Spearman’s R = −0.53).
Fig 3: Schematic presentation of correlations between TPP2 mRNA, PSMB8 mRNA and IVL mRNA and significantly related clinical features in groups of AD, PV and C. In all the patients, TPP2 mRNA corelated positively with PSMB8 mRNA, suggesting the cooperation of both molecules in the skin, in any stage. PSMB8 mRNA correlated positively with IVL mRNA only in an inflammation state, and was elevated in both AD and PV, but not in healthy skin. PSMB8 mRNA corelated positively with skin lesions extension (BSA) in AD and with inflammation in a single lesion (I-PSI) in PV. min—minimal values, med—medial values, max—max values.
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