Fig 1: The restricted cubic spline (RCS) model fitting the association between serum ATGL and renal function. Adjustments were made for sex, age, fatty liver, and smoking. Solid lines represent multivariable adjusted β, and dashed lines represent 95% CIs obtained from restricted cubic spline regression. (a) Dose–response of serum ATGL and eGFR. (b) Dose–response of serum ATGL and UACR.
Fig 2: Expression differences of different DKD-related parameters in different serum ATGL quartiles. (a) UACR in different serum ATGL levels. (b) 24 h-UTP in different serum ATGL levels. (c) eGFR in different serum ATGL levels. (d) SCr in different serum ATGL levels. (e) BUN in different serum ATGL levels. (f) UA in different serum ATGL levels. (g) TNFR-1 in different serum ATGL levels. (h) KIM-1/Cr in different serum ATGL levels. Data were expressed as the mean ± SD. ∗p < 0.05,∗∗p < 0.01.
Fig 3: Contents of serum ATGL, urine KIM-1/Cr, and serum TNFR-1 in different groups. (a) The level of serum ATGL in HC group, DM group, L-DKD group, and H-DKD group. (b) The level of urinary KIM-1/Cr in HC group, DM group, L-DKD group, and H-DKD group. (c) The level of serum TNFR-1 in HC group, DM group, L-DKD group, and H-DKD group. Data were expressed as the mean ± SD. ∗p < 0.05,∗∗p < 0.01.
Fig 4: Correlation between serum ATGL and DKD parameters. (a) Correlation between serum ATGL- and DKD-related parameters (diabetes duration, UACR, 24 h-UTP, SCr, BUN, UA, TNFR-1, and KIM-1/Cr) based on Spearman's correlation test. (b) Sensitivity and specificity based on ROC curve (ATGL, eGFR, and eGFR + ATGL). (c) Sensitivity and specificity based on ROC curve (ATGL, KIM-1/Cr, and KIM-1/Cr + ATGL).
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