Fig 1: Correlation network of key ASVs, metabolites, immune indicators and clinical phenotypes. (A) Correlation in the key ASVs, metabolites and clinical phenotypes. (B) Correlation in the key ASVs, metabolites and immunocytes. (C) Correlation in the key ASVs, metabolites and inflammatory factors. Red connections indicate the positive correlation (FDR < 0.05), whereas blue connections show correlations that were negative (FDR < 0.05). ASV, amplicon sequence variant; FT3, free triiodothyronine; FT4, free tetraiodothyronine; TSH, thyroid-stimulating hormone; TgAb, thyroglobulin antibody; TPOAb, anti-thyroid peroxidase antibody; TRAb, thyroid stimulating hormone receptor; NB,native B cells; PB, preswitched memory B cells; DB, double-negative memory B cells; CB, conventional memory B cells; PC, plasma cells; LPS, lipopolysaccharide; LBP, LPS-binding protein; BAFF, B-cell-activating factor; APRIL, a proliferation-inducing ligand.
Fig 2: Levels of lipopolysaccharide (LPS) and LPS-binding protein (LBP) in serum according to corticosteroid therapy at baseline (Mann-Whitney test for LPS p = 0.058) in patients with rheumatoid arthritis. Statistical significance was considered when p < 0.05. * Indicates a trend toward significance (p = 0.058).
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