Fig 1: In healthy volunteers, aspirin 300 mg administered for 28 days led to a reduction in serum prostaglandin E2 (PGE2; Panel B) and netrin-1 (Panel C), as well as thromboxane B2 (TXB2; Panel A). The reduction in netrin-1 was associated with increased serum salicylate levels (Panel E), while there was a positive correlation between netrin-1 and PGE2 levels (Panel F). There was no change in markers of endothelial dysfunction, vascular cell adhesion molecule-1 (VCAM-1; Panel G), intracellular adhesion molecule (ICAM-1; Panel H), or E-selectin (Panel I). High-sensitivity C-reactive protein (hs-CRP) levels remained unchanged post treatment (Panel J). Western blotting was performed to identify both the full length, 70 kDa netrin-1 protein and the truncated, 55 kDa netrin-1 protein, but only the truncated isoform was detected (Panel D).
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