Fig 1: Effects of WYD on enteral transit rate and serological parameters in mice with LIA. (A) Enteral transit ratio; (B) MTL; (C) Gas; (D) SP; (E) AChE; and (F) VIP in mice with LIA by ELISA. Contradistinguished with the No group, #, P<0.05, ##, P<0.01; compared with the Lop + Saline group, *, P<0.05, **, P<0.01. Mice were grouped as follows: No: NC group; Lop + Saline: Lop and saline were used to cure the mice; Lop + WYD-L: Lop and WYD at 10.2 g/kg BW were used to cure the mice; Lop + WYD-M: Lop and WYD at 20.4 g/kg BW were used to cure the mice; Lop + WYD-H: Lop and WYD at 40.8 g/kg BW were used to cure the mice; Lop + Pur: Lop and prucalopride at 0.26 mg/kg BW were used to cure the mice. Lop, loperamide; WYD, Wenyang Yiqi Decoction; Pru, prucalopride; LIA, loperamide-induced astriction; MTL, motilin; Gas, gastrin; SP, substance P; AChE, acetylcholinesterase; VIP, vasoactive intestinal peptide; ELISA, enzyme-linked immunosorbent assay; BW, body weight.
Fig 2: Effect of CCACPs on inflammatory factors in serum, skin and AChE, SOD in brain and ALT and AST in liver of mice irradiated by D-gal injection combined with UVB.(A) Serum levels of IL-6 in mice. (B) Levels of IL-6 in mice skin. (C) Levels of AChE in mice brain. (D) Levels of SOD in mice brain. (E) Levels of ALT in mice liver. (F) Levels of AST in mice liver. (*p < 0.05, **p < 0.01, ***p < 0.001, in relation to D-gal injection combined with UVB irradiation controls; ##p < 0.01, ###p < 0.001, in relation to control group).
Fig 3: The effect of BPA and/or vanadium on the levels of neurotransmitters in the prefrontal cortex of the mice. (A) level of AChE, (B) level of Serotonin, and (C) level of Dopamine. The data obtained was analyzed using one-way ANOVA (***P < 0.0001). The values are presented as means ± SD (n = 5/group).
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