Description
Superoxide dismutase (SOD) are metalloenzymes that catalyze the dismutation of superoxide radical into hydrogen peroxide (H2O2) + molecular oxygen (O2) and consequently provide an important defense mechanism against superoxide radical toxicity. Oxidative stress dependent upon superoxide radical can account for a number of acute and chronic disease states, which include inflammation and ischemia-reperfusion. SOD protects murine peritoneal macrophages from apoptosis induces by adriamycine. Furthermore over expression of SOD in fibrosarcome cells protect against apoptosis and promote cell differentiation