Fig 1: Plasma DAMPs were differently regulated in COVID-19 patients. Plasma concentration of S1008/A9 (A), HMGB1 (B), SP-A (C), and CIRBP (D) in healthy donors (HDs, n = 9) or COVID-19 patients at admission (n = 28) and discharge (n = 19; sample at discharge stage for SPA-A analysis: n = 13) as analyzed by ELISA. Data are expressed as mean ± SD. Two-tailed Mann-Whitney U test, ∗P < 0.05; ∗∗P < 0.01. HMGB1: histones and high mobility group box 1; SP-A: sufactant protein A; CIRBP: cold-inducible RNA-binding protein; HD: Health Donors.
Fig 2: Receiver operating characteristic (ROC) analysis of plasma DAMPs in COVID-19 patients and healthy donors (HDs). The sensitivity and specificity for both COVID-19 patients and HDs were calculated. The ROC curves of S100A8/A9 (A), HMGB1(B), SP-A (C), CIRBP(D) were plotted and the area under the curve (AUC) was calculated with the 95% confidence intervals (CIs) based on DeLong's method.
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