Description
Product Characteristics: The AssayMax™ Mouse Serum Amyloid P Component ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for detection of mouse SAP in plasma, serum, and cell culture samples. This assay employs a quantitative sandwich enzyme immunoassay technique that measures mouse SAP in approximately 4 hours. A polyclonal antibody specific for mouse SAP has been pre-coated onto a 96-well microplate with removable strips. Mouse SAP in standards and samples is sandwiched by the immobilized antibody and the biotinylated polyclonal antibody specific for mouse SAP, which is recognized by a streptavidin-peroxidase conjugate. All unbound material is washed away and a peroxidase enzyme substrate is added. The color development is stopped and the intensity of the color is measured.
Target Information: The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]