Description
Product Characteristics: This immunoassay kit allows for the in vitro quantitative determination ofmouseadenomatous polyposis coli protein,mAPCconcentrations in serum, Plasma,tissue homogenates and Cell culture supernates and Other biological fluids.
Target Information: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]