Description
Product Characteristics: The AssayMax™ Rat Plasminogen ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for detection of rat plasminogen in plasma, serum, urine, and cell culture samples. This assay employs a quantitative sandwich enzyme immunoassay technique that measures rat plasminogen in less than 4 hours. A polyclonal antibody specific for rat plasminogen has been pre-coated onto a 96-well microplate with removable strips. Plasminogen in standards and samples is sandwiched by the immobilized antibody and the biotinylated polyclonal antibody specific for rat plasminogen, which is recognized by a streptavidin-peroxidase conjugate. All unbound material is washed away and a peroxidase enzyme substrate is added. The color development is stopped and the intensity of the color is measured.
Target Information: The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]