Description
Product Characteristics: This immunoassay kit allows for the in vitro quantitative determination ofratDNA-(apurinic or apyrimidinic site) lyaseconcentrations in serum, Plasma,tissue homogenates and Cell culture supernates and Other biological fluids.
Target Information: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene\, all encode the same protein. [provided by RefSeq, Jul 2008]