Description
The oxidation of low density lipoprotein is thought to be one of the first steps in atherosclerosis. The uptake of oxidized LDL (oxLDL) by macrophages activates pro-inflammatory mediators that promote disease progression. Cayman’s Oxidized LDL Uptake Assay Kit is a convenient tool to study modulators of cellular uptake of oxLDL. The kit employs a fluorescently tagged, human oxLDL along with myricetin, an inhibitor of uptake that reduces CD36 expression. The reagents provided in this kit are sufficient to run a single plate of cultured cells by either FC or FM