Fig 1: Effects of THC and PPC lipid carrier with/without losartan in diabetic CKD rats. BP, blood pressure; CKD, chronic kidney disease; CrCl, creatinine clearance; CTL, control animals; KIM-1, kidney injury molecule-1; PPC, polyenylphosphatidylcholine; THC, tetrahydrocurcumin. *p < 0.05 vs. CTL, **p < 0.01 vs. CTL, ***p < 0.001 vs. CTL; #p < 0.05 vs. CKD; o p < 0.05 vs. THC + PPC.
Fig 2: Effect of glycyrrhizin on the mRNA expression of kidney injury markers and serum lactate dehydrogenase (LDH). (A-C) Relative expressions of KIM-1, NGAL and IL-18 mRNA were measured using RT-PCR. The mRNA expression of kidney injury markers was significantly higher in the PC-AKI group compared to the controls, whereas it was significantly lower in the PC-AKI with glycyrrhizin group. (D) Compared to the control group, serum LDH levels significantly increased in PC-AKI, whereas they decreased with glycyrrhizin pretreatment. Results were expressed as means ± SEMs. N = 8 for each group. Statistical significance: *P < 0.05 and ***P < 0.001 Con vs PC-AKI and Con vs PC-AKI + GL, #P < 0.05 and ##P < 0.01 PC-AKI vs GL + PC-AKI. Abbreviation: PC-AKI, post-contrast acute kidney injury; GL, glycyrrhizin; LDH, lactate dehydrogenase.
Supplier Page from Abcam for Rat KIM-1 ELISA Kit