Fig 1: Transfer of FcγRIIB+ but not FcγRIIB– CD8+ T cells into an Fgl2-rich environment results in loss of transferred T cells.(A–C) Naive B6 animals were infected either LCMV Arm or cl-13, and serum was analyzed on days 3, 7, 14, and 21 after infection for the concentration of total IgG (A), serum amyloid protein (SAP) (B), or Fgl2 (C). (D–H) Naive B6 animals received an adoptive transfer of 1 × 104 congenically labeled CD45.1+ P14 T cells and were infected with LCMV Arm. On day 27, splenic CD45.1+CD8+ P14 T cells were sorted into FcγRIIB+ (Fcpos) and FcγRIIB– (Fcneg) populations which were each transferred into naive hosts that were then infected with either Arm or cl-13 (D). (E and F) The frequency (E) and absolute number (F) of FcγRIIB+ (Fcpos) versus FcγRIIB– (Fcneg) CD45.1+ CD8+ among PBMC in Arm-infected mice. (G and H) The frequency (G) and absolute number (H) of FcγRIIB+ (Fcpos) versus FcγRIIB– (Fcneg) CD45.1+ CD8+ among PBMC in cl-13–infected mice. Data shown are n = 3–5 mice/group and are representative of 2 independent experiments. Data at each time point were compared by Mann-Whitney U nonparametric test and are depicted as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.