pGL4.43[luc2P/XRE/Hygro] Vector from Promega

Product Specs
ItempGL4.43[luc2P/XRE/Hygro] Vector
CompanyPromega
Price Supplier Page View Company Product Page
Catalog NumberE4121
Quantity20microg
Molecular Weight~68kDa
Nucleic Acid TypeReporter Vectors
Expression System (standardized)Mammalian
Vector NamepGL4.43[luc2P/XRE/Hygro]

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Promega

2800 Woods Hollow Rd

Madison, WI 53711

United States

Phone: Tel: +1 (608) 274-4330
Fax: +1 (608) 277-2516

Email: custserv@promega.com
techserv@promega.com

Company Profile

Website: http://www.promega.com

(1) Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitisFront PharmacolDecember 11, 2025Shangrui Rao, Yi Mei, Lingyan Shi, Hongzheng Li, Minyu Zhou, Ziyu Meng, Zhijie Zhao, Shaotang Li, Weijian Sun, Qiang TianVazyme, China), and a HiScript III RT SuperMix kit (R323-01, Vazyme, China) were purchased. XREM-luc (E4121) and pRL (E2261) plasmids were purchased from Promega. The cDNA sequence of PXR was cloned into the

(2) Respiratory syncytial virus downregulates the airway aryl hydrocarbon receptor pathway: implication for the development of a novel therapeutic targetAmerican Journal of Physiology-Lung Cellular and Molecular PhysiologyDecember 1, 2025Aline Haas Haas de Mello, Yue Qu, Tianshuang Liu, Roberto P. Garofalo, Antonella CasolaμL). Luciferase reporter assay A549 cells were transfected with pGL4.43[luc2P/XRE/Hygro] (Promega Cat# E4121 Part# E412A), a designed vector that uses an optimized luc2 firefly luciferase gene in the pGL4 backbone.

(3) Discovery of a novel binding pocket in PPARγ for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesisFront ChemMay 8, 2025Zhen Wang, Kexin Shui, Zehui Zhang, Yihan Chen, Nanfei Yang, Shiliang Ji, Pingping Shen, Qiang TianStates), and a AceQ qPCR SYBR Green Master Mix kit (Q111-02, Vazyme, China), were purchased. PPRE-luc (E4121) and pRL (E2261) plasmids were purchased from Promega. The cDNA sequence of PPARγ was cloned into the

(4) Oklahoma nitrone-007 is an effective anticancer therapeutic agent targeting inflammatory and immune metabolism pathways in endometrial cancerThe Journal of Pharmacology and Experimental TherapeuticsJanuary 1, 2025Sugantha Priya Elayapillai, Anjalika Gandhi, Samrita Dogra, Debra Saunders, Nataliya Smith, Cole Hladik, Rheal A. Towner, Katherine M. Moxley, Bethany N. Hannafonxenobiotic response element (XRE) activity was measured using the pGL4.43 (luc2P/XRE/Hygro) construct (E4121; Promega). CS-99, ARK-1, and Ishikawa cells were reverse transfected with 2 μg firefly luciferase reporter

(5) Identification of an alternative ligand‐binding pocket in peroxisome proliferator‐activated receptor gamma and its correlated selective agonist for promoting beige adipocyte differentiationMedComm (2020)July 10, 2024Qiang Tian, Miaohua Wang, Xueting Wang, Zhenli Lei, Owais Ahmad, Dianhua Chen, Wei Zheng, Pingping Shen, Nanfei Yangspecies assay kit (S0033S, Beyotime), and Griess reagent (S0024, Beyotime), were purchased. PPRE‐luc (E4121) and pRL (E2261) plasmids were purchased from Promega. The cDNA sequence of mouse PPARγ was cloned into

(6) Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathwaysCell reportsJuly 25, 2023Ganapathy AS, Saha K, Wang A, Arumugam P, Dharmaprakash V, Yochum G, Koltun W, Nighot M, Perdew G, Thompson TA, et al.MA",RRID:Addgene_90339 pGL4.74,"Promega, Madison, WI",Cat# E6921 luc2P/XRE pGL4.43,"Promega, Madison, WI",Cat #E4121 luc2P/ARE pGL4.37,"Promega, Madison, WI",Cat# E3641 pGL4.26,"Promega, Madison, WI",Cat #E8441 pCRISPR-

(7) Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor ResponsesCellMay 17, 2018Iyer SS, Gensollen T, Gandhi A, Oh SF, Neves JF, Collin F, Lavin R, Serra C, Glickman J, de Silva PSA, et al.9166 C57BL/6,Taconic,Cat# B6 Recombinant DNA,Recombinant DNA,Recombinant DNA pGL4.43 Luc2pXRE,Promega,Cat# E4121 pGL4.75,Promega,Cat# E6931 Renilla luciferase,Promega,Cat# E2261 Software and Algorithms,Software

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