Description
The vector of anti-ACE2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target SARS-CoV-2 (COVID-19) ACE2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-ACE2 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Others