Description
The BDC-2.5 and BDC-10.1 CD4 T cell clones both weakly react with the naturally occurring 358-371 cleavage product (WE14) of chromogranin A (ChgA), a bioactive peptide precursor found in the secretory vesicles of endocrine cells and neurons. The BDC-2.5 CD4 T cells also were reported to recognize a distinct hormonal polypeptide derived from ChgA, the vasostatin-1–derived peptide ChA (29–42)