Description
GuK1, also known as GMK, belongs to the guanylate kinase family. This protein exists as a monomer that catalyzes the ATP-dependent conversion of GMP to GDP, thereby playing an essential role in the recycling of GMP. Via its catalytic activity, GuK1 is thought to participate in regulating the supply of guanine nucleotides to signal transduction pathways. Overexpression of GuK1 is associated with pituitary adenocarcinomas, suggesting that GuK1 is involved in tumorigenesis