Fig 1: SF3B2 is de-fatty acylated by HDAC11.(A) SF3B2 was chosen as a potential substrate after cross-referencing three mass spectrometry datasets. (B) Co-IP of SF3B2 and HDAC11. (C) SF3B2 lysine fatty acylation by Alk14. (D) Quantification of C. (E) SF3B2 K fatty acylation with WT or catalytically dead Y304H HDAC11. (F) Quantification of E. (G) Relative quantification of E. Each condition is normalized by dividing by the +Alk14 signal from its paired control.Each shape in the dot plots represents an independent experiment. Statistics are by paired T-test. *p<0.05, **p<0.01, ns: not significant (p>0.05).