Laboratory services are available from specialized providers in molecular biology, biochemistry, immunology, proteomics, and other research areas. By leveraging the technologies and expertise of these life science service providers, teams can save time and effort to focus on bigger projects. The process for utilizing laboratory services found through Biocompare typically involves a few key steps, which can vary slightly depending on the specific service and provider. Begin by browsing for the right service using the provided filters on the left. Once you find services of interest, visit the company page or submit a quote for more information. Many service providers offer a consultation phase where you can discuss your project in detail, including your objectives, the type of analysis or service you need, and any specific requirements or questions you may have. This is a good time to ask about sample preparation, shipping instructions, timelines, and costs.
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- Amplicon-seq™ enables high-sensitivity confirmation of on- and off-target mutations in edited cell lines and tissues of interest. Targeted amplicon sequencing is guided by data from nomination assays (ONE-seq, GUIDE-seq™, etc.), enabling precise ...
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- SAFER Detection™ confirms on-target, off-target and homology-mediated structural rearrangements resulting from gene editing, addressing regulatory expectations for structural rearrangement data, including large deletions, inversions, and chromosomal ...
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- CHANGE-seq is an unbiased, sensitive, high-throughput biochemical method for off-target nomination. CHANGE-seq uses circularized genomic DNA that is treated in vitro with the editor of interest, followed by selective sequencing of on- and off-target ...
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- DEUX-seq™ is a biochemical, orthogonal nomination assay to ONE-seq™ findings to support regulatory requirements. DEUX-seq leverages in vitro cleavage of genomic DNA with the editor of interest followed by whole genome sequencing and identification of...
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- GUIDE-seq™ is a cell-based, orthogonal nomination assay that enables genome-wide, unbiased identification of nuclease-cleaved double-stranded breaks at on- and off-target sites. GUIDE-seq uses cotransfection of a dsODN tag with the gene-editing ...
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- ONE-seq is the gold-standard, variant-aware nomination assay for comprehensive identification of potential off-target effects for the gene-editing tool of interest. ONE-seq leverages in silico on- and off-target enumeration, followed by in vitro ...
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- Guide Profiler™ is an in silico tool that enables rapid screening of multiple guide RNAs in parallel, allowing researchers to preview potential off-target effects, and cost-effectively narrow down candidates during early discovery and target ...
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- Guide Select™ is a biochemical screening assay based on the ONE-seq™ platform that enables variant-aware, off-target risk assessment for multiple guide RNAs in parallel. Guide Select can de-risk early cell and gene therapy development through precise...
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