Laboratory services are available from specialized providers in molecular biology, biochemistry, immunology, proteomics, and other research areas. By leveraging the technologies and expertise of these life science service providers, teams can save time and effort to focus on bigger projects. The process for utilizing laboratory services found through Biocompare typically involves a few key steps, which can vary slightly depending on the specific service and provider. Begin by browsing for the right service using the provided filters on the left. Once you find services of interest, visit the company page or submit a quote for more information. Many service providers offer a consultation phase where you can discuss your project in detail, including your objectives, the type of analysis or service you need, and any specific requirements or questions you may have. This is a good time to ask about sample preparation, shipping instructions, timelines, and costs.
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- High-precision quantitative measurement of a drug compound and/or its metabolites in various biological matrices (urine, blood, plasma, serum, etc.).
- Validation of developed methods to ensure compliance with current regulatory bioanalytical guidelines.
- Predict if exposure to a test article will result in decreased clearance of drugs co-administered with the test article.
- Identify cytochrome P450 (CYP) isoforms involved in drug metabolism that are responsible for metabolism of a compound in vitro and can support in vivo data to identify active metabolites.
- Cell permeability screening assay uses Caco-2 cells and incubations in transwell plates.
- Predict risk of cholestatic hepatotoxicity using the novel C-DILI™ Assay.
- Review of preclinical and clinical data to provide insights and practical recommendations to minimize risk and accelerate the path to regulatory approval.
- Determine if an investigational drug is a transporter inhibitor and a potential perpetrator in transporter-mediated drug-drug interactions.
- Determine if a test article is a transporter substrate and a potential victim in transporter-mediated drug-drug interactions.
- Identify the species with the closest induction profile to humans.
- Assess test article accumulation, clearance, and DDI potential in hepatocytes using B-CLEAR® technology.
- Evaluate the potential for up-regulation of cytochrome P450 (CYP) enzymes.
- Determine and profile the enzymatic metabolites and biotransformation pathways of test articles.
- Met ID is used to determine how many/which metabolites are formed and the percent of parent exposure (AUC).
- In vitro definitive study designed to evaluate inhibition and uptake (mechanistic determination) to predict lysosomotropic behavior.
- Mechanistic tox assays use in vitro methods to investigate how test articles cause toxicity.
- Predict the metabolic clearance of a compound over time.
- In vitro Microsomal and Plasma Protein Binding assays use Equilibrium Dialysis to determine free drug concentration (fraction unbound) in plasma.
- Predictive toxicology assays use in vitro methodologies to forecast potential toxic effects of a test article.
- Model the potential for drug candidates to bind to red blood cell (RBCs) and predict the distribution of drug candidates between plasma and RBCs.
- Predict if exposure to a test article will result in decreased expression of UDP-glucuronosyltransferase (UGT) enzymes.
- Identify UDP-glucuronosyltransferase (UGT) enzymes involved in drug metabolism in vitro.
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