Description
Nitrosation is the reaction introducing nitroso (-NO) to the carbon or nitrogen atoms of organic molecules. The commonly used reagents for nitrosation are nitrous acid (nitrite plus acid) and nitrite. Compared with nitro compounds, nitroso groups possess the nature of unsaturated bonds so that they can be reduced, oxidized, condensed and added to produce various types of intermediates, which have an important application value in drug synthesis. Since the nitrosation are an exothermic process, a low temperature is thought to be favorable for the reaction. Having recognized the fact that almost all of the nitro compounds are unstable and easy to be decomposed, the nitrosation should be, therefore, elaborately designed and strictly controlled or monitored.