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Covaris LLC

14 Gill St, Unit H

Woburn, Massachusetts 01801-1721

United States

Phone: +1 781-932-3959
Fax: +1 781-932-8705

Email: info@covaris.com

Company Profile

Website: www.covaris.com

(1) CRISPR-Cas9-mediated homology-directed repair rescues the induced bone marrow failure in Fancc -/- miceMolecular Therapy Nucleic AcidsJune 16, 2026Hemavathy Harikrishnan, Mahesh Lamsal, Ka-Kui Chan, Junping Zhang, Jiahe Tian, Kwadwo Fosu, Hong Phuong Nguyen, D. Wade Clapp, Elizabeth A. Sierra Potchanant, Reuben Kapur, et al.quantified from gel electrophoresis. AAV integration assay Genomic DNA was fragmented via (cat. no. 520079, Covaris) at 6,000 rpm 60 s to get approximate 10-kb DNA fragments. Fragmented DNA were cleavage by

(2) Targeted long-read RNA sequencing for rare disease diagnosis and variant interpretationSci AdvApril 17, 2026Robert Wang, Feng Wang, Nicole DeBruyne, Xinjun Ji, Nicole M. Engelhardt, Joseph Jee-Hwan Park, Amber Notaro, Samantha Gaerlan, Ryan Park, Matthew J. Schultz, et al.respectively. Extracted DNA was sheared to a target fragment size of 20 kbp using a g-TUBE (Covaris, #520079), and ~1 μg of sheared DNA was used to make nanopore 1D sequencing libraries according to the ONT ligation

(3) Oxford Nanopore enhanced accuracy of long-read amplicons applied to microbial whole-genome sequencingMicrobiology SpectrumApril 7, 2026Marion Helsmoortel, Erwin Sentausa, Adrien Villain, Viet-Dung Tran, Emmanuelle Santiago-Allexant, Corinne Beaulieu, Amy Hesketh, Josephine Abi-Ghanem, Philippe Leissner, Adrien Salioupreparation: DNA fragmentation Mechanical fragmentation involved hydrodynamic shearing in Covaris g-TUBEs (520079, Covaris) using benchtop centrifugation. In the development and validation of the protocol, 150 ng of

(4) Efficient multi-kilobase knock-ins in mice and cell lines using CRISPR/Cas9 and rAAV donors with unbiased whole-genome characterization by LOCK-seqNucleic Acids ResApril 7, 2026Monica F Sentmanat, Zi Teng Wang, Evguenia Kouranova, Samuel T Peters, Wan Ching Chan, Jed Lin, Yong Miao, J Michael White, Mia Wallace, Xiaoxia CuiMonarch Genomic DNA Purification Kit (NEB, cat. #T3010S) was loaded onto a Covaris g-TUBE (Covaris, cat. #520079) and centrifuged at 4900 × g for 1 min to generate fragments in the 10 kb size range. Fragmented DNA

(5) Whole genome sequence of the syntrophic fatty acid-degrading bacterium Syntrophomonas curvata GB8-1 TMicrobiology Resource AnnouncementsMarch 12, 2026Ethan Humm, Neil Q. Wofford, Jessica R. Sieber, Marco Morselli, Matteo Pellegrini, Michael J. McInerney, Sung Min Ha, Robert P. GunsalusMagbead Plus Kit per the manufacturer’s instructions. DNA was fragmented using g-Tubes (Covaris, cat# 520079) in an Eppendorf 5424 centrifuge for 60 s at 3,000 × g for a total of 3 spins according to the manufacturer’s

(6) Development of a Novel Method to Detect AAV Vector IntegrationVirusesMarch 3, 2026Junping Zhang, Thao Thi Dang, Tsai-Yu Lin, Xiangping Yu, Danilo Pellin, Jiahe Tian, Olga Simmons, Emma Kou, Kenneth Cornetta, Weidong Xiao332659, Waltham, MA, USA) and sheared into approximately 10 kb DNA fragments by a g-TUBE (Covaris, 520079, Woburn, MA, USA). The DNA fragments were dephosphorylated by FastAP™ thermosensitive alkaline phosphatase

(7) Scalable and comprehensive mosaic variant calling using DRAGENmedRxivFebruary 4, 2026Sairam Behera, Massimiliano Rossi, Yina Wang, Michal B Izydorczyk, Duke Tran, Clifton L Dalgard, Ester Kalef-Ezra, Kavya Kottapalli, Heer Mehta, Gavin Parnaby, et al.Agilent Femto Pulse. Starting with ~10 μg of DNA, samples were sheared using g-tubes (Covaris Part number 520079) to an average size of 18–22 kb. Sheared DNA was size-selected on the PippinHT instrument (Sage Science)

(8) Astronauts as a Human Aging Model: Epigenetic Age Responses to Space ExposureAging CellFebruary 1, 2026Matías Fuentealba, JangKeun Kim, Jeremy Wain Hirschberg, Bader Shirah, Eliah G. Overbey, Christopher Mason, David FurmanKit for Cells & Blood (cat # T3050L). We sheared the extracted HMW gDNA using Covaris G‐Tubes (cat # 520079) down to a target size of 20 kb. We measured fragment length using Genomic ScreenTape (Agilent, cat

(9) Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypesPLOS PathogensJanuary 13, 2026Ghazal Sadri, Steven T. Nadakal, William Lauer, Justin Kos, Parmit K. Singh, Erin Elliott, Catherine W. Kaiser, Easton E. Ford, Nadia Richardson, Kaitlyn M. Shields, et al.(2.5 μg) of HMW gDNA per sample was mechanically sheared to 10–15 kb fragments using g-TUBE (Covaris, #520079). Centrifugation was performed at 4100 rpm using an Eppendorf 5242R microcentrifuge. The sheared gDNA

(10) Fine mapping regulatory variants by characterizing native CpG methylation with nanopore long-read sequencingHuman Genetics and Genomics AdvancesJanuary 1, 2026Yijun Tian, Shannon K. McDonnell, Lang Wu, Nicholas B. Larson, Liang Wangwith RNase A treatment included. The genomic DNA was sheared into 8 kb fragments with g-TUBE (Covaris, 520079). The sheared DNA was used for PCR-free nanopore sequencing library preparation using the Ligation Sequencing

(11) A curated protein dataset for taxonomic classification of Prochlorococcus and Synechococcus in metagenomesSci DataDecember 3, 2025Allison Coe, James I. Mullet, Nhi N. Vo, Paul M. Berube, Maya I. Anjur-Dietrich, Eli Salcedo, Sierra M. Parker, Konnor VonEmster, Christina Bliem, Aldo A. Arellano, et al.and stored at −80 °C. Genomic DNA samples were diluted and fragmented to 10–12 Kb using a gTube (cat# 520079, Covaris), followed by a 0.45X SPRIselect (cat# B23317, Beckman Coulter Life Sciences) bead cleanup.

(12) Single cell long read whole genome sequencing reveals somatic transposon activity in human brainCommunications BiologyNovember 20, 2025Michal B. Izydorczyk, Ester Kalef-Ezra, Dominic W. Horner, Xinchang Zheng, Nadine Holmes, Marco Toffoli, Zeliha Sahin, Yi Han, Heer H. Mehta, Sonja W. Scholz, et al.final volume of 50 µL. For shearing, 3 µg of diluted DNA was processed using Covaris g-tubes (Covaris 520079), with each sample passed four times through the tube orifice via centrifugation at 3,800 rpm. Following

(13) Long-read metagenomics for strain tracking after faecal microbiota transplantNature MicrobiologyOctober 22, 2025Yu Fan, Mi Ni, Varun Aggarwala, Edward A. Mead, Magdalena Ksiezarek, Lei Cao, Michael A. Kamm, Thomas J. Borody, Sudarshan Paramsothy, Nadeem O. Kaakoush, et al.Prior to library preparation, genomic DNA was sheared using Covaris g-tubes (Covaris, Woburn, MA, USA 520079) at 6000 RPM in an Eppendorf 5424R centrifuge (Eppendorf, Enfield, CT, USA, 5406000640) and cleaned

(14) Population-scale Long-read Sequencing in the All of Us Research ProgrammedRxivOctober 16, 2025Kiran V Garimella, Qiuhui Li, Julie Wertz, Samuel K Lee, Fabio Cunial, Yongqing Huang, Yulia Mostovoy, Ryan Lorig-Roach, Adam English, Hang Su, et al.DNA was diluted to 60 ng/μL using nuclease free water to a volume of 50 μL. Covaris g-tubes (Covaris 520079) were used for shearing starting with 3 μg of the diluted DNA. Each sample was passed four times through

(15) A Strategy for Single-Run Sequencing of the Water Buffalo Genome: (I) the Use of Third-Generation Technology to Quickly Produce Long, High-Quality ReadsAnimals (Basel)October 15, 2025Federica Di Maggio, Marcella Nunziato, Elvira Toscano, Leandra Sepe, Roberta Cimmino, Emanuela Antonella Capolongo, Alessandra Vasco, Giovanni Paolella, Francesco Salvatorevolume of 60 µL. Subsequently, fragmentation was performed using the Covaris g-TUBEs (Covaris Cat. No. 520079) to obtain DNA fragments between 20 and 30 kbases. Moreover, to verify the fragmentation, the samples

(16) Complete genome sequence of Diaporthe vaccinii Shear, a fungal isolated from blueberryMicrobiology Resource AnnouncementsOctober 9, 2025Xiufen Wang, Rong Lei, Xin Li, Limei Li, Xinyi Wanglong-read sequencing libraries were prepared through mechanical DNA fragmentation (Covaris g-Tube, Cat# 520079) coupled with nucleic acid purification via Beckman AMPure XP Reagent (Cat# A63881), followed by enzymatic

(17) Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminaseNature MethodsOctober 1, 2025Heejin Roh, Simon P. Shen, Yan Hu, Hui Si Kwok, Allison P. Siegenfeld, Ceejay Lee, Marcanthony U. Zepeda, Chun-Jie Guo, Shelby A. Roseman, Caroline Comenho, et al.-whole genome sequencing gDNA extracted after the DddA reaction was fragmented to 10 kb size using Covaris G-tubes (Covaris 520079), and DNA concentration was measured with a Qubit fluorometer. Nanopore DNA libraries were then generated

(18) Whole Genome Sequencing and Extracellular Metabolite Profiling of Lactiplantibacillus plantarum FRT4: Insights into Probiotic FunctionalityBiology (Basel)September 1, 2025Yuyin Huang, Kun Meng, Guohua Liu, Zhimin Chen, Yunsheng Han, Peilong Yang, Rui Zhang, Hongying CaiSequencing Kit and Native Barcoding Kit SQK-NBD114.24. DNA (2 μg) was fragmented using Covaris g-TUBE (Cat 520079), followed by end-repair and dA-tailing using the NEBNext FFPE DNA Repair Mix and Ultra II End-Prep

(19) LongTrack: long read metagenomics-based precise tracking of bacterial strains and their genomic changes after fecal microbiota transplantationbioRxivAugust 11, 2025Yu Fan, Mi Ni, Varun Aggarwala, Edward A. Mead, Magdalena Ksiezarek, Lei Cao, Michael A. Kamm, Thomas J. Borody, Sudarshan Paramsothy, Nadeem O. Kaakoush, et al.library preparation, genomic DNA (gDNA) was sheared using Covaris g-tubes (Covaris, Woburn, MA, USA 520079) at 6000 RPM in an Eppendorf 5424R centrifuge (Eppendorf, Enfield, CT, USA, 5406000640) and cleaned

(20) NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodelingNature GeneticsJuly 21, 2025Xiaodong Lu, Viriya Keo, Irina Cheng, Wanqing Xie, Galina Gritsina, Juan Wang, Lina Lu, Cheng-Kai Shiau, Yueying He, Qiushi Jin, et al.Quick-DNA Miniprep Plus Kit (Zymo, D4068) and fragmented to an average size of 8 kb using g-TUBE (Covaris, 520079). DNA libraries were prepared with the Ligation Sequencing Kit (ON SQK-LSK110) following the manufacturer’s

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