SignalSilence ® mTOR siRNA II from Cell Signaling Technology

Product Specs
ItemSignalSilence ® mTOR siRNA II
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6556S
Quantity300 µl
TargetmTOR
NCBI Gene AliasesFRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
NCBI Full Gene Namemechanistic target of rapamycin kinase
Research AreaPI3K / Akt Signaling
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosisNature communicationsNovember 22, 2021Meng Y, Davies KA, Fitzgibbon C, Young SN, Garnish SE, Horne CR, Luo C, Garnier JM, Liang LY, Cowan AD, et al.hTNF-Fc62 was produced in-house, while the Smac mimetic, Compound A63 and the pan-caspase inhibitor, IDN-6556/Emricasan, were provided by Tetralogic Pharmaceuticals. The RIPK3 inhibitors, GSK′843 (ref. 54) and

(2) Gene-activated matrix harboring a miR20a-expressing plasmid promotes rat cranial bone augmentationRegenerative biomaterialsMarch 1, 2021Shido R, Sumita Y, Hara M, Iwatake M, Narahara S, Umebayashi M, Miura KI, Kodama Y, Asahina I.Antibodies,"Company, Catalog No." Rabbit polyclonal anti-GFP antibody,"Abcam, #6556" Rabbit polyclonal anti-PPARγ antibody,"CST, #2435" Rabbit polyclonal anti-BMP4 antibody,"Abcam, #39973" Mouse

(3) A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndromeNatureSeptember 1, 2020Napolitano G, Di Malta C, Esposito A, de Araujo MEG, Pece S, Bertalot G, Matarese M, Benedetti V, Zampelli A, Stasyk T, et al.otherwise. The following siRNAs were used: siRNA Rheb1 I (#14267), siRNA mTOR I (#6381), siRNA mTOR II (#6556) were from Cell Signaling; Human RRAGD siRNA (L-016120-00) and non-targeting siRNA Pool (D-001810-10-05)

(4) Tanshinone IIA reverses EGF‑ and TGF‑β1‑mediated epithelial‑mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathwayOncology LettersNovember 1, 2019Longkai Zhang, Weibin Lin, Xiaodan Chen, Gang Wei, Hailong Zhu, Shangping Xingincubated with the corresponding secondary antibodies conjugated to fluorescein isothiocyanate (cat. 6556 ONCOLOGY LETTERS 18: 6554-6562, 2019 no. 4412; 1:1,000; Cell Signaling Technology, Inc.) for 1 h at

(5) Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2−/− miceScientific ReportsDecember 1, 2018Roja Barikbin et al.

(6) YAP-associated chromosomal instability and cholangiocarcinoma in miceOncotargetJanuary 19, 2018Rizvi S, Fischbach SR, Bronk SF, Hirsova P, Krishnan A, Dhanasekaran R, Smadbeck JB, Smoot RL, Vasmatzis G, Gores GJ.

(7) Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and primingNature CommunicationsAugust 1, 2017Marcial Camacho, Jayeeta Basu, Thorsten Trimbuch, Shuwen Chang, Cristina Pulido-Lozano, Shwu-Shin Chang, Irina Duluvova, Masin Abo-Rady, Josep Rizo, Christian RosenmundG-Dynabeads (Thermo Scientific, Hampton, NH, USA) bound to the antibody (Ab) Rabbit anti-GFP (Abcam 6556) or control Ab Rabbit IgG (Cell Signaling 2729S). The Dynabeads-Ab-Antigene (Ag) c were washed three

(8) The drebrin/EB3 pathway drives invasive activity in prostate cancerOncogeneJuly 20, 2017Dart AE, Worth DC, Muir G, Chandra A, Morris JD, McKee C, Verrill C, Bryant RJ, Gordon-Weeks PR.

(9) Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone FormationInternational Journal of Molecular SciencesMarch 7, 2017Gui-Xun Shi, Xin-Feng Zheng, Chao Zhu, Bo Li, Yu-Ren Wang, Sheng-Dan Jiang, Lei-Sheng Jiang

(10) Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2EMBO molecular medicineJanuary 1, 2017Loforese G, Malinka T, Keogh A, Baier F, Simillion C, Montani M, Halazonetis TD, Candinas D, Stroka D.

(11) Mfsd2a+ hepatocytes repopulate the liver during injury and regenerationNature communicationsNovember 18, 2016Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, et al.

(12) Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinomaThe international journal of biochemistry & cell biologySeptember 1, 2016Vallianou I, Dafou D, Vassilaki N, Mavromara P, Hadzopoulou-Cladaras M.

(13) Novel approaches to target HER2-positive breast cancer: trastuzumab emtansineCancer Management and ResearchJune 9, 2016Gonzalo Recondo, Gonzalo Recondo Jr, Fernando Galanternik, Fernando Galanternik, Bernardo Amadeo DÃaz-CantÃ³n, Bernardo Amadeo Leoneratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer. 2004;5(1):63–69. 4. Lemmon MA, Schlessinger J. Cell signaling

(14) Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcomaMolecular cancerAugust 7, 2014Imura Y, Yasui H, Outani H, Wakamatsu T, Hamada K, Nakai T, Yamada S, Myoui A, Araki N, Ueda T, et al.siRNAs targeting c-MET (constructs I and II; #6618 and #6622) and mTOR (construct I and II; #6381 and #6556), and a non-targeting siRNA (#6568) were purchased from Cell Signaling Technology, Inc. Soft agar colony

(15) Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiologyNature communicationsJanuary 1, 2013Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, Pradere JP, Schwabe RF.

(16) Essential roles of mTOR/Akt pathway in Aurora-A cell transformationInternational journal of biological sciencesJune 19, 2009Taga M, Hirooka E, Ouchi T.samples were washed with NET-N buffer and subjected to SDS-PAGE. siRNA Assay Synthesized siRNA (#6381 and #6556) were purchased from Cell Signaling and tested for suppression. Briefly, U2OS cells were seeded at 30%

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