SignalSilence ® mTOR siRNA I from Cell Signaling Technology

Product Specs
ItemSignalSilence ® mTOR siRNA I
CompanyCell Signaling Technology
Price $369.00 Inquire
Catalog Number6381S
Quantity300 µl
TargetmTOR
NCBI Gene AliasesFRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
NCBI Full Gene Namemechanistic target of rapamycin kinase
Research AreaPI3K / Akt Signaling
ReactivityH
ApplicationssiRNA
TypesiRNA

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Single-cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemiaCell Reports MedicineDecember 19, 2023Oto Inoue, Chiaki Goten, Daiki Hashimuko, Kosei Yamaguchi, Yusuke Takeda, Ayano Nomura, Hiroshi Ootsuji, Shinichiro Takashima, Kenji Iino, Hirofumi Takemura, et al.CD271+ progenitors at 20–30% confluence were transfected with 60 nM SignalSilence mTOR siRNA I (CST, #6381) or control siRNA (CST, #6568) using lipofectamine RNAiMAX Transfection Reagent (Invitrogen) according

(2) PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanismMolecular oncologyJanuary 1, 2022Simula L, Antonucci Y, Scarpelli G, Cancila V, Colamatteo A, Manni S, De Angelis B, Quintarelli C, Procaccini C, Matarese G, et al.been used: siERK1/2 (Cell Signaling 6560), siCTRL (Santa Cruz sc‐37007), and simTOR (Cell Signaling 6381). 2.12 Statistical analysis In the Figure legends, ‘n’ indicates either the number of independent

(3) A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndromeNatureSeptember 1, 2020Napolitano G, Di Malta C, Esposito A, de Araujo MEG, Pece S, Bertalot G, Matarese M, Benedetti V, Zampelli A, Stasyk T, et al.hours unless stated otherwise. The following siRNAs were used: siRNA Rheb1 I (#14267), siRNA mTOR I (#6381), siRNA mTOR II (#6556) were from Cell Signaling; Human RRAGD siRNA (L-016120-00) and non-targeting

(4) Bifunctional ligand design for modulating mutant p53 aggregation in cancerâ€ â€ Electronic supplementary information (ESI) available: Experimental procedures, synthetic schemes, 1H and 13C NMR characterization, pKa values, speciation diagrams, Zn affinity determination and respective HypSpec data fitting, and NCI-60 in vitro cytotoxicity data for LI and LH (PDF). Crystallographic data for ZnLICl and ZnLHCl (CIF). CCDC 1947980 and 1947981. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9sc04151fChemical ScienceDecember 14, 2019Jessica J. Miller, AnaÃ¯s Blanchet, Christophe Orvain, Lucienne Nouchikian, Yasmin Reviriot, Ryan M. Clarke, Diego Martelino, Derek Wilson, Christian Gaiddon, Tim Storrprogression, Cell. Signalling, 2017, 33, 49–58; (c) D. P. Lane, p53, guardian of the genome, Nature, 1992, 358(6381), 15–16; (d) T. Riley, E. Sontag, P. Chen and A. Levine, Transcriptional control of human p53-regulated

(5) A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling RolesCancer DiscoveryNovember 1, 2017Vito W. Rebecca et al.Cell Signaling Technology SignalSilence® Rheb siRNA I (#14267) and siRNA II (#14284), mTOR siRNA (#6381S), and ATG5 siRNA (#6345), along with Control siRNA (#6568) per manufacturers protocol. Electron Microscopy Electron microscopy

(6) A unified approach to targeting the lysosome’s degradative and growth signaling rolesCancer DiscovSeptember 12, 2017Vito W. Rebecca, Michael C. Nicastri, Noel McLaughlin, Colin Fennelly, Quentin McAfee, Amruta Ronghe, Michel Nofal, Chun-Yan Lim, Eric Witze, Cynthia I. Chude, et al.Cell Signaling Technology SignalSilence® Rheb siRNA I (#14267) and siRNA II (#14284), mTOR siRNA (#6381S), and ATG5 siRNA (#6345), along with Control siRNA (#6568) per manufacturers protocol. Electron Microscopy Electron microscopy

(7) Insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancerOncology reportsNovember 1, 2015Du Y, Long Q, Shi Y, Liu X, Li X, Zeng J, Gong Y, Li L, Wang X, He D.(Hs_RPS6KB1_5) and control (1022076) siRNAs were purchased from Qiagen (Valencia, CA, USA), and mTOR (6381) and control (6568) siRNAs were purchased from Cell Signaling Technology (Beverly, MA, USA). Transfection

(8) Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR PathwayPloS oneJanuary 1, 2015Kumar D, Das B, Sen R, Kundu P, Manna A, Sarkar A, Chowdhury C, Chatterjee M, Das P.p-PI3Kp85(Tyr458)/p55(Tyr199) (4228), LY294002 (9901) and siRNA against Atg 5 (6345), Bax (6321), Akt (6211), mTOR (6381) and siControl (6568) were procured from Cell Signaling Technology (Inc. Beverly, MA, USA). Cyto-ID® Autophagy detection kit

(9) DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1OncotargetJanuary 1, 2015Selvarajah J, Elia A, Carroll VA, Moumen A.Crawley, UK,) according to the manufacturer's instructions and as previously described [55]. mTOR siRNA (#6381) was purchased from Cell Signaling (New England Biolabs, Hitchin, UK), Raptor (sc-44069) and Rictor

(10) Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcomaMolecular cancerAugust 7, 2014Imura Y, Yasui H, Outani H, Wakamatsu T, Hamada K, Nakai T, Yamada S, Myoui A, Araki N, Ueda T, et al.kinds of siRNAs targeting c-MET (constructs I and II; #6618 and #6622) and mTOR (construct I and II; #6381 and #6556), and a non-targeting siRNA (#6568) were purchased from Cell Signaling Technology, Inc. Soft

(11) Type I interferons induce autophagy in certain human cancer cell linesAutophagyMay 1, 2013Schmeisser H, Fey SB, Horowitz J, Fischer ER, Balinsky CA, Miyake K, Bekisz J, Snow AL, Zoon KC.6-well plates and immediately transfected for 48 h with 100 nM SignalSilenceR MTOR siRNA (Cell Signaling 6381), or SignalSilenceR control siRNA (Cell Signaling 6568), using 5 µg LipofectamineTM 2000 (Invitrogen,

(12) mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosisCancer researchMarch 15, 2013Zhao L, Yue P, Khuri FR, Sun SY.synthesized by Qiagen (Valencia, CA). mTOR siRNA was purchased from Cell Signaling Technology, Inc (Cat. # 6381). Transfection of these siRNA duplexes was conducted in 6-well plates using the HiPerFect transfection reagent

(13) mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosisCancer Res.January 14, 2013Liqun Zhao, Ping Yue, Fadlo R. Khuri, Shi-Yong Sunsynthesized by Qiagen (Valencia, CA). mTOR siRNA was purchased from Cell Signaling Technology, Inc (Cat. # 6381). Transfection of these siRNA duplexes was conducted in 6-well plates using the HiPerFect transfection reagent

(14) Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibitionCell death & diseaseJune 7, 2012Jin HO, Hong SE, Woo SH, Lee JH, Choe TB, Kim EK, Noh WC, Lee JK, Hong SI, Kim JI, et al.TX, USA), S6K1 (Hs_RPS6KB1_5) and control (1022076) siRNAs from Qiagen (Valencia, CA, USA) and mTOR (6381) and control (6568) siRNAs from Cell Signaling Technology (Beverly, MA, USA). Transfection experiments

(15) Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathwayJournal of EndocrinologyAugust 1, 2009Francisco Altamirano, César Oyarce, Patricio Silva, Marcela Toyos, Carlos Wilson, Sergio Lavandero, Per Uhlén, Manuel Estradainterference RNA to mTOR (siRNA–mTOR) was obtained from Cell Signaling Technology (catalog number #6381, Danvers, MA, USA). After 24 h of cultures, cells grown on 60 mm dishes were transfected with siRNA– mTOR

(16) Essential roles of mTOR/Akt pathway in Aurora-A cell transformationInternational journal of biological sciencesJune 19, 2009Taga M, Hirooka E, Ouchi T.samples were washed with NET-N buffer and subjected to SDS-PAGE. siRNA Assay Synthesized siRNA (#6381 and #6556) were purchased from Cell Signaling and tested for suppression. Briefly, U2OS cells were seeded

(17) Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPsRNAJuly 1, 2008Liwei Rong et al.nucleus is caused by fixation or other manipulations of available siRNA (Cell Signaling Technology, no. 6381) the cells, living cells transiently expressing 4E-BP1-CFP failed to alter 4E-BP1 subcellular localization

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