SignalSilence ® Control siRNA (Unconjugated) from Cell Signaling Technology

Product Specs
ItemSignalSilence ® Control siRNA (Unconjugated)
CompanyCell Signaling Technology
Price $162.00 Inquire
Catalog Number6568S
Quantity150 µl
Conjugate/Tag/LabelUnconjugated
Research AreaRelated Products
ApplicationssiRNA
TypesiRNA
ReactivityAll

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) An Integrative Proteotranscriptomics Approach Reveals New ADAM9 Substrates and Downstream PathwaysMolecular & Cellular ProteomicsApril 1, 2026Congyu Lu, Xiaolu Xu, Neha Sindhu, Jessica Rainey, Yuhan Zhang, Shawn W. Polson, Jing Qiu, Shuo WeiSupplemental Table S8. The siRNAs used in this study include control siRNA (Cell Signaling Technology [CST], 6568), ADAM9 siRNA-1 (AD9-1) (CST, 11968), and ADAM9 siRNA-2 (AD9-2) (Ambion, 4390826). Antibodies used in

(2) Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancerWorld J Gastrointest OncolFebruary 15, 2026Xi Lin, Guo-Feng Lin, Fei-Teng Gu, Yong-Liang LiChina) for lentiviral production. β-catenin small interfering RNA (siRNA) (#6225) and control siRNA (#6568) were purchased from Cell Signaling Technology, MA, United States. Stable cell lines were screened with

(3) Akt inhibition enhances the antitumor efficacy of immune checkpoint blockades and radiotherapy in a syngeneic breast cancer modelMolecular Therapy OncologyDecember 18, 2025Nawon Park, Seung Hyuck Jeon, Yoomin Kim, Seongmin Kim, In Ah Kim204-14) for 24–48 h. Cells were then transfected with control siRNA (Cell Signaling Technology, USA, 6568s) or Akt-specific siRNA (Cell Signaling Technology, USA, 6211s) for 36 h. After treatment, cells were

(4) Nicotine-Induced VEGF Levels in NSCLC Cells Are Modulated by PKA, Hyaluronan, and p53International Journal of Molecular SciencesNovember 17, 2025Caroline Wozniak, Alvaro Cobos, Aya Sabri, Stuti Goel, Brooke Lopo, Sarah Sarofim, Chanidapa Chutipassakul, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evanspurchased from ThermoFisher. SignalSilence p53 siRNA I (6231), SignalSilence control siRNA (unconjugated, 6568), PKA C-α (D38C6) rabbit mAb #5842, and p53 rabbit antibody (9282) were purchased from Cell Signaling Technology

(5) Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survivalFEBS Open BioSeptember 23, 2025Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy EvansThermo Fisher, Waltham, MA, USA. SignalSilence p53 siRNA I (6231), SignalSilence control siRNA (Unconjugated, 6568), and p53 rabbit antibody (9282) were purchased from Cell Signaling Technology, Danvers, MA, USA. Goat

(6) Atypical cadherin FAT1 promotes tumorigenesis by suppressing autophagic cell death in glioblastoma under hypoxia or nutrient stressCellular & molecular biology lettersSeptember 3, 2025Gupta Y, Goswami S, Arora M, Malik N, Irshad K, Kundu A, Gowda SH, Kapoor M, Gupta S, Nag TC, et al.Finkel’s lab), siLC3B (CST, USA, cat. no. 6313; 150 nM/transfection) or siControl (CST, USA, cat. no. 6568; 150 nM/transfection), using Lipofectamine-3000™ reagent (Invitrogen, USA, cat. no. L3000015; 3 μl/μg

(7) Designed gramicidin-inspired stabilized peptide-based therapeutics to potentiate immunotherapy against aggressive kidney cancer†Biomaterials ScienceAugust 19, 2025Argha Mario Mallick, Ananya Chatterjee, Arun Bahadur Gurung, Prithviraj Uttarasili, Archana Tripathi, Monjuri Hembram, Anand Srivastava, Rituparna Sinha Royconstructing GUVs were sourced from Avanti Polar Lipids. SignalSilence control siRNA (unconjugated) (cat. no. 6568) was obtained from Cell Signaling Technology. Annexin V, Alexa Fluor 488 conjugate (cat. no. A13201),

(8) CF10/LV overcomes acquired resistance to 5-FU/LV in colorectal cancer cells through downregulation of the c-Myc/ABCB5 axisCancer Drug ResistanceJuly 15, 2025Charles Chidi Okechukwu, William H. Gmeiner5FU + LV and non-treated cells were exposed to 100 nM control siRNA (Cell Signaling Technology Cat# 6568) and c-Myc siRNA (Cell Signaling Technology Cat# 6341) for 48 h as recommended by the vendor. The cells

(9) Evolution-guided design of mini-protein for high-contrast in vivo imagingActa Pharmaceutica Sinica BJuly 15, 2025Nongyu Huang, Yang Cao, Guangjun Xiong, Suwen Chen, Juan Cheng, Yifan Zhou, Chengxin Zhang, Xiaoqiong Wei, Wenling Wu, Yawen Hu, et al.per well and incubated for 24 h. HER2 siRNA I (#6282, Cell Signaling Technology) and control siRNA (#6568, Cell Signaling Technology) were transfected into the cells using Lipofectamine™ 3000 (Invitrogen) according

(10) Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma CellsCancer Res CommunJune 6, 2025Stacia L. Koppenhafer, Elizabeth L. Geary, Mary V. Thomas, Emma E. Croushore, Jessica A.O. Zimmerman, Jenna M. Gedminas, Dawn E. Quelle, Rebecca D. Dodd, David J. Gordonaccording to the manufacturer’s instructions. siControl was obtained from Cell Signaling Technology (#6568; refs. 48, 49). siMCM2 was obtained from IDT (hs.Ri.MCM2.13.1 and hs.Ri.MCM2.13.2). siHDAC1, siHDAC2,

(11) S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasisNat CommunApril 27, 2025Ashima Sakhuja, Ritobrata Bhattacharyya, Yash Tushar Katakia, Shyam Kumar Ramakrishnan, Srinjoy Chakraborty, Hariharan Jayakumar, Shailesh Mani Tripathi, Niyati Pandya Thakkar, Sumukh Thakar, Sandeep Sundriyal, et al.small-interfering RNA (SignalSilence® Ezh2 siRNA I #6509) and control siRNA (SignalSilence® Control siRNA#6568) were obtained from Cell Signaling Technology. eNOS siRNA was designed (Sense: 5′ GAA GAG GAA GGA GUC

(12) Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesisCell Mol Biol LettApril 10, 2025Sichuan Xi, Jigui Shan, Xinwei Wu, Haitao Wang, Mary R. Zhang, Shakirat Oyetunji, Hong Xu, Zuoxiang Xiao, Tuana Tolunay, Shamus R. Carr, et al.siRNA/shRNAs (sc-37007, Santa Cruz Biotechnology Inc.; 4,390,844, ThermoFisher; SIC001, Millipore; 6568, Cell Signaling), utilizing Invitrogen Lipofectamine 2000. Target gene knockdown was verified using

(13) Inhibitory Activity of Sparassis latifolia on the Lipid Accumulation through Suppressing Adipogenesis and Activating Lipolysis in 3T3-L1 CellsJournal of Microbiology and BiotechnologyOctober 28, 2024Jeong Won Choi, Hyeok Jin Choi, Rhim Ryoo, Youngki Park, Kyoung Tae Lee, Jin Boo Jeongagainst PGC-1α (sc-518025) was purchased from Santa Cruz Biotechnology, Inc. (USA). Control siRNA (#6568) and β-catenin siRNA (#sc-29210) were purchased from Cell Signaling Technology, Inc. and Santa Cruz

(14) ATG10S promotes IFNL1 expression and autophagic degradation of multiple viral proteins mediated by IFNL1AutophagyOctober 1, 2024Zhang MQ, Li JR, Yang L, Peng ZG, Wu S, Zhang JP.concentration of 5 nM for 30 h. The ATG7-specific siRNA (6604) and its corresponding negative control siRNA (6568) were obtained from Cell Signaling Technology, and transfected into cells at 100 nM for 30 h. Then the

(15) EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma CellsInternational Journal of Molecular SciencesAugust 6, 2024Emma E. Croushore, Christopher S. Stipp, David J. Gordon5′-UUUCGUCUUGGGAAGAAUACUG-3′) was obtained from IDT, and siControl was obtained from Cell Signaling Technology (#6568). 4.8. TO-RRM1-KO Cell Lines TO-RRM1-KO cell lines were generated as previously described [15]. A

(16) Identification of Poliovirus Receptor-like 3 Protein as a Prognostic Factor in Triple-Negative Breast CancerCellsAugust 3, 2024Gian Marco Leone, Katia Mangano, Salvatore Caponnetto, Paolo Fagone, Ferdinando Nicolettivalidated siRNA for EZH2 (6509, Cell Signaling Technology, Danvers, MA, USA) or a negative control (6568, Cell Signaling Technology), using Lipofectamine 2000 reagent following the manufacturer’s instructions.

(17) Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinomaBiomedicine & PharmacotherapyAugust 1, 2024Silvia Brambillasca, Maria Rosaria Cera, Adrian Andronache, Sumit Kumar Dey, Giovanni Fagá, Daniele Fancelli, Emanuela Frittoli, Maurizio Pasi, Michela Robusto, Mario Varasi, et al.coverslip; SignalSilence siRNA oligos were from Cell Signaling Technologies (GSK3α/βː #6301; control: #6568). Cells were analyzed 72 h upon transfection, after an overnight incubation with starvation medium (1

(18) Anticancer Activity of Delta-Tocotrienol in Human Hepatocarcinoma: Involvement of Autophagy InductionCancersJuly 26, 2024Montagnani Marelli M, Macchi C, Ruscica M, Sartori P, Moretti RM.Small Interfering RNA (siRNA) To silence endogenous ATG5 expression, negative control (NC) siRNA (#6568) and ATG5 siRNA I (#6345) obtained from Cell Signaling were used. HepG2 were seeded in 6-well culture

(19) CD11b maintains West Nile virus replication through modulation of immune response in human neuroblastoma cellsVirology JournalJuly 14, 2024Yan-Gang Liu, Hao-Ran Peng, Rui-Wen Ren, Ping Zhao, Lan-Juan Zhao(Catalog number stB0001176A; Ribobio, Guangzhou, China) or Signal Silence Control siRNA (Catalog number 6568; Cell Signaling Technology) was transfected into cells at a final concentration of 100 nM using Lipofectamine

(20) Interleukin-1β induces and accelerates human endometrial stromal cell senescence and impairs decidualization via the c-Jun N-terminal kinase pathwayCell Death DiscoveryJune 15, 2024Robert N. Taylor, Sarah L. Berga, Eric Zou, Jacara Washington, Sunyangzi Song, Brandon J. Marzullo, Indrani C. Bagchi, Milan K. Bagchi, Jie Yuconstructs or a scrambled duplex control purchased from Cell Signaling Technologies (cat# 6232, 6233 and 6568), were introduced into ESC via transient transfection at a concentration of 100 nmol per well using

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